ArticlePLoS genetics2015
Fascin1-dependent Filopodia are required for directional migration of a subset of neural crest cells.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Deep learning reveals the complex genetic architecture of male guppy colouration.Nature ecology & evolution · 2025Article
- A simple and scalable zebrafish model of Sonic hedgehog medulloblastoma.Cell reports · 2024Article
- SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy.Acta biochimica et biophysica Sinica · 2024Article
- Genetic regulation of enteric nervous system development in zebrafish.Biochemical Society transactions · 2024Review
- Article
- The actin bundling protein Fascin is important for proper early development in Strongylocentrotus purpuratus embryos.microPublication biology · 2023Article
- How filopodia respond to calcium in the absence of a calcium-binding structural protein: non-channel functions of TRP.Cell communication and signaling : CCS · 2022Article
- A ROR2 coding variant is associated with craniofacial variation in domestic pigeons.Current biology : CB · 2021Article
- Review
- Podoplanin Drives Motility of Active MacrophageFrontiers in immunology · 2021Article
- Article
- Review
- Transcriptomic profiling of microglia and astrocytes throughout aging.Journal of neuroinflammation · 2020Article
- Neural crest development: insights from the zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- Article
- Endodermal pouch-expressedBiology open · 2018Article
- Comparison of solvate ionic liquids and DMSO as an in vivo delivery and storage media for small molecular therapeutics.BMC biotechnology · 2018Article
- Interleukin-10 reorganizes the cytoskeleton of mature dendritic cells leading to their impaired biophysical properties and motilities.PloS one · 2017Article
- Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation.Nature communications · 2016Article
- Signaling filopodia in vertebrate embryonic development.Cellular and molecular life sciences : CMLS · 2016Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Directional migration of neural crest (NC) cells is essential for patterning the vertebrate embryo, including the craniofacial skeleton. Extensive filopodial protrusions in NC cells are thought to sense chemo-attractive/repulsive signals that provide directionality. To test this hypothesis, we generated null mutations in zebrafish fascin1a (fscn1a), which encodes an actin-bundling protein required for filopodia formation. Homozygous fscn1a zygotic null mutants have normal NC filopodia due to unexpected stability of maternal Fscn1a protein throughout NC development and into juvenile stages. In contrast, maternal/zygotic fscn1a null mutant embryos (fscn1a MZ) have severe loss of NC filopodia. However, only a subset of NC streams display migration defects, associated with selective loss of craniofacial elements and peripheral neurons. We also show that fscn1a-dependent NC migration functions through cxcr4a/cxcl12b chemokine signaling to ensure the fidelity of directional cell migration. These data show that fscn1a-dependent filopodia are required in a subset of NC cells to promote cell migration and NC derivative formation, and that perdurance of long-lived maternal proteins can mask essential zygotic gene functions during NC development.
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