ArticleCell cycle (Georgetown, Tex.)2015
Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device.
Article in Cell cycle (Georgetown, Tex.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
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- Enzyme Is the Name-Adapter Is the Game.Cells · 2024Review
- Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies.Signal transduction and targeted therapy · 2023Review
- Meta-Dynamic Network Modelling for Biochemical Networks.Methods in molecular biology (Clifton, N.J.) · 2023Article
- NF-kB in Signaling Patterns and Its Temporal Dynamics Encode/Decode Human Diseases.Life (Basel, Switzerland) · 2022Review
- Feedback, Crosstalk and Competition: Ingredients for Emergent Non-Linear Behaviour in the PI3K/mTOR Signalling Network.International journal of molecular sciences · 2021Review
- Regulation of MST complexes and activity via SARAH domain modifications.Biochemical Society transactions · 2021Review
- Mapping connections in signaling networks with ambiguous modularity.NPJ systems biology and applications · 2019Article
- Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR.Scientific reports · 2018Article
- A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.Nature communications · 2016Article
- MST1/MST2 Protein Kinases: Regulation and Physiologic Roles.Biochemistry · 2016Review
- Ras signaling through RASSF proteins.Seminars in cell & developmental biology · 2016Review
- Article
- MST2-RASSF protein-protein interactions through SARAH domains.Briefings in bioinformatics · 2016Article
- Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling.Journal of molecular medicine (Berlin, Germany) · 2016Review
- A Regulated Double-Negative Feedback Decodes the Temporal Gradient of Input Stimulation in a Cell Signaling Network.PloS one · 2016Article
- The dynamic control of signal transduction networks in cancer cells.Nature reviews. Cancer · 2015Review
- DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How do biochemical signaling pathways generate biological specificity? This question is fundamental to modern biology, and its enigma has been accentuated by the discovery that most proteins in signaling networks serve multifunctional roles. An answer to this question may lie in analyzing network properties rather than individual traits of proteins in order to elucidate design principles of biochemical networks that enable biological decision-making. We discuss how this is achieved in the MST2/Hippo-Raf-1 signaling network with the help of mathematical modeling and model-based analysis, which showed that competing protein interactions with affinities controlled by dynamic protein modifications can function as Boolean computing devices that determine cell fate decisions. In addition, we discuss areas of interest for future research and highlight how systems approaches would be of benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.