Evidence map›Paper›PMID 25607452›Full record

ArticleImmunity2015

Self-determination in the T cell repertoire.

Michael E Birnbaum, K Christopher Garcia

Abstract readComment
In one paragraph

Article in Immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Michael E BirnbaumDepartments of Molecular and Cellular Physiology and Structural Biology, Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: mbirnb@stanford.edu.
K Christopher GarciaDepartments of Molecular and Cellular Physiology and Structural Biology, Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: kcgarcia@stanford.edu.

Funding

TCR recognition of MHC class II peptide compexes in multiple sclerosisP01AI045757 · NIAID · DANA-FARBER CANCER INSTITUTE · PI WUCHERPFENNIG, KAI W · 1999 to 2017
$22.8M
Structural correlates of T cell receptor signalingR01AI103867 · NIAID · STANFORD UNIVERSITY · PI Kenan Christopher GARCIA · 2014 to 2026
$5.3M
Howard Hughes Medical InstituteNIAID NIH HHS P01 AI045757NIAID NIH HHS R01 AI103867
6 · The paper itself

Abstract

The number of T cells specific for various antigens can vary dramatically. In this issue of Immunity, Nelson et al. (2015) report that these differences might be, at least in part, set by the number of cross-reactive self peptides encountered by T cells during development.

Indexed as

AnimalsCD4-Positive T-LymphocytesEncephalomyelitis, Autoimmune, ExperimentalHumansMultiple SclerosisMyelin-Oligodendrocyte GlycoproteinPeptide FragmentsMyelin-Oligodendrocyte GlycoproteinPeptide Fragments

Identifiers

PMID25607452
PMCPMC4456669

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.