Evidence map›Paper›PMID 25607446›Full record

ArticleThe New England journal of medicine2015

Hidden formaldehyde in e-cigarette aerosols.

R Paul Jensen, Wentai Luo, James F Pankow, Robert M Strongin, David H Peyton

4 registry-linked trialsAbstract readLetter
PubMed Publisher
In one paragraph

Article in The New England journal of medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 277 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
277citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03463837 nacompletednot on this mapstarted 2018, after this paper: background citation

A Randomized, Open-Label, Parallel-Group Study to Characterize Biomarkers of Tobacco Exposure and Nicotine Uptake From JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adult Smokers

TypeinterventionalSponsorJuul Labs, Inc.Ran2018 to 2018Enrolled90ConditionsNicotine Dependence, Other Tobacco Product, Tobacco Use, Smoking, TobaccoArmsTreatment with JUUL 5%, Virginia Tobacco, Treatment with JUUL 5%, Cool Mint, ENDS, Treatment with JUUL 5%, Mango, ENDS, JUUL 5%, Creme Bruele, ENDS, Combustible cigarette
NCT03719391 nacompletednot on this mapstarted 2018, after this paper: background citation

A Randomized, Open-Label, Cross-Over Study to Assess Nicotine Uptake and Subjective Measures With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) Compared to Usual Brand Combustible Cigarettes, a Comparator E-Cigarette, and Nicotine Gum in Healthy Adult Smokers

TypeinterventionalSponsorJuul Labs, Inc.Ran2018 to 2018Enrolled67ConditionsNicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco SmokingArmsVirginia Tobacco flavored JUUL 5% ENDS, Cool Mint flavored JUUL 5% ENDS, Mango flavored JUUL 5% ENDS, Creme Brulee flavored JUUL 5% ENDS, VUSE Solo e-cigarette
NCT04107779 nacompletednot on this mapstarted 2019, after this paper: background citation

A Randomized, Open Label, Parallel Group Study in Adult Smokers to Evaluate Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to Using JUUL Electronic Nicotine Delivery Systems With Two Different Nicotine Concentrations

TypeinterventionalSponsorJuul Labs, Inc.Ran2019 to 2020Enrolled279ConditionsElectronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco SmokingArmsSwitch from UB of Combustible Cigarette to JUUL 5% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mint ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Mint ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Menthol ENDS
NCT04123041 nacompletednot on this mapstarted 2019, after this paper: background citation

A Randomized, Open-Label, Cross-Over Study to Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems With Multiple Flavors and Nicotine Concentrations, Usual Brand of Combustible Cigarettes, a Comparator E-Cigarette and Nicotine Gum in Adult Smokers

TypeinterventionalSponsorJuul Labs, Inc.Ran2019 to 2019Enrolled137ConditionsElectronic Cigarette Use, Tobacco SmokingArmsJUUL ENDS, Combustible cigarette, comparator e-cigarette, Nicorette gum
3 · Its place in the literature

Who cites it

277 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Exposure to Heated Tobacco Products and Adverse Health Effects, a Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  2. Pooled it
  3. Five-Day Changes in Biomarkers of Exposure Among Adult Smokers After Completely Switching From Combustible Cigarettes to a Nicotine-Salt Pod System.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
    Trial
  4. Trial
  5. Type of E-Cigarette Device Used Among Adolescents and Young Adults: Findings From a Pooled Analysis of Eight Studies of 2166 Vapers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018
    Trial
  6. Review
  7. E-cigarette use and Barrett's esophagus: evaluating a new risk in the era of vaping.Esophagus : official journal of the Japan Esophageal Society · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Influence of e-cigarettes and their constituents on cardiac rhythm and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

217 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

R Paul JensenPortland State University, Portland, OR peytond@pdx.edu.
Wentai Luo
James F Pankow
Robert M Strongin
David H Peyton

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Electronic Nicotine Delivery SystemsAerosolsFormaldehydeHumansMagnetic Resonance SpectroscopyParticulate MatterPropylene GlycolRiskSolventsAerosolsFormaldehydeParticulate MatterPropylene GlycolSolvents

Identifiers

PMID25607446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.