ReviewExercise and sport sciences reviews2015
TGF-β superfamily signaling in muscle and tendon adaptation to resistance exercise.
Review in Exercise and sport sciences reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02597660 (A Double-Blind Placebo-Controlled Study to Evaluate the Efficacy of Somatropin in the Treatment of Patellar Tendinopathy), which is not on this map. Cited by 77 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Double-Blind Placebo-Controlled Study to Evaluate the Efficacy of Somatropin in the Treatment of Patellar Tendinopathy
Who cites it
77 citing papers in PubMed, 122 citations in OpenAlex.
- NSAIDs trigger drug-specific response to exercise: a multi-omics systems biology analysis of a randomized crossover trial.Skeletal muscle · 2026Trial
- The Use of Recombinant Human Growth Hormone to Protect Against Muscle Weakness in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Pilot, Randomized Placebo-Controlled Trial.The American journal of sports medicine · 2020Trial
- Acute resistance exercise modulates microRNA expression profiles: Combined tissue and circulatory targeted analyses.PloS one · 2017Trial
- Increasing skeletal muscle mass and strength during incretin-based weight loss.Obesity pillars · 2026Article
- Regulators of ECM structure enable functional adaptation to tensile loading in tendon explants.Matrix biology : journal of the International Society for Matrix Biology · 2026Article
- Highly bio-adapted hydrogels for tendon-bone interface regeneration: Natural healing inspiration, design strategies, and biomedical potential.Bioactive materials · 2026Review
- Regulators of ECM Structure Enable Functional Adaptation to Tensile Loading in Tendon Explants.bioRxiv : the preprint server for biology · 2026Article
- Article
- Myostatin in Obesity: A Molecular Link Between Metabolic Dysfunction and Musculotendinous Remodeling.International journal of molecular sciences · 2026Review
- The Transforming Growth Factor β Genes and Susceptibility to Musculoskeletal Injuries in a Physically Active Caucasian Cohort.Journal of clinical medicine · 2026Article
- Article
- Tendon Dysfunction in Collagen VI-Related Myopathies: Novel Mechanistic Insights with Therapeutic Potential.International journal of molecular sciences · 2025Review
- Single-cell transcriptomics analysis of the healing process of ligament rupture.Bone & joint research · 2025Article
- Cisplatin-Induced Muscle Wasting and Atrophy: Molecular Mechanism and Potential Therapeutic Interventions.Journal of cachexia, sarcopenia and muscle · 2025Review
- Dynamic changes of molecular pattern and cellular subpopulation in puncture-induced tendon injury model.iScience · 2025Article
- Parallel Chondrogenesis and Osteogenesis Tissue Morphogenesis in Muscle Tissue via Combinations of TGF-β Supergene Family Members.Cartilage · 2025Article
- Platelet-rich Plasma in Orthopedics: Unraveling Cellular Mechanisms, Therapeutic Potential, and Limitations : Platelet-rich Plasma in Orthopedics.Galen medical journal · 2025Review
- Network model of skeletal muscle cell signalling predicts differential responses to endurance and resistance exercise training.Experimental physiology · 2024Article
- Molecular insights of exercise therapy in disease prevention and treatment.Signal transduction and targeted therapy · 2024Review
- A role for TGFβ signaling in Gli1+ tendon and enthesis cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Numerous studies in muscle and tendon have identified a central role of the transforming growth factor-β (TGF-β) superfamily of cytokines in the regulation of extracellular matrix growth and remodeling, protein degradation, and cell proliferation and differentiation. We provide a novel framework for TGF-β and myostatin signaling in controlling the coordinated adaptation of both skeletal muscle and tendon tissue to resistance training.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.