ArticlePloS one2015
Analysis of putative apoplastic effectors from the nematode, Globodera rostochiensis, and identification of an expansin-like protein that can induce and suppress host defenses.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 62 citations in OpenAlex.
- Functional roles of miR862b in regulating soybean resistance to Heterodera glycines.Plant cell reports · 2025Article
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- CgNis1's Impact on Virulence and Stress Response inInternational journal of molecular sciences · 2024Article
- Insights into the plant response to nematode invasion and modulation of host defense by plant parasitic nematode.Frontiers in microbiology · 2024Review
- Comparative genomics among cyst nematodes reveals distinct evolutionary histories among effector families and an irregular distribution of effector-associated promoter motifs.Molecular ecology · 2023Article
- Transcriptome Analysis of Fusarium-Tomato Interaction Based on an Updated Genome Annotation ofJournal of fungi (Basel, Switzerland) · 2022Article
- Identification and characterization of putative effectors fromFrontiers in plant science · 2022Article
- Soybean miR159International journal of molecular sciences · 2021Article
- Potato cyst nematodes Globodera rostochiensis and G. pallida.Molecular plant pathology · 2021Article
- Oxylipins are implicated as communication signals in tomato-root-knot nematode (Meloidogyne javanica) interaction.Scientific reports · 2021Article
- Identification of the Complex Interplay Between Nematode-Related lncRNAs and Their Target Genes inFrontiers in plant science · 2021Article
- Molecular and Cellular Mechanisms Involved in Host-Specific Resistance to Cyst Nematodes in Crops.Frontiers in plant science · 2021Review
- Molecular insights into the compatible and incompatible interactions between sugar beet and the beet cyst nematode.BMC plant biology · 2020Article
- UhAVR1, an HR-Triggering Avirulence Effector ofJournal of fungi (Basel, Switzerland) · 2020Article
- A novel effector CfEC92 of Colletotrichum fructicola contributes to glomerella leaf spot virulence by suppressing plant defences at the early infection phase.Molecular plant pathology · 2020Article
- Initial responses of the trap-crop, Solanum sisymbriifolium, to Globodera pallida invasions.The plant genome · 2020Article
- Article
- Article
- The potato cyst nematode effector RHA1B is a ubiquitin ligase and uses two distinct mechanisms to suppress plant immune signaling.PLoS pathogens · 2019Article
- Functional analysis of apple stem pitting virus coat protein variants.Virology journal · 2019Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The potato cyst nematode, Globodera rostochiensis, is an important pest of potato. Like other pathogens, plant parasitic nematodes are presumed to employ effector proteins, secreted into the apoplast as well as the host cytoplasm, to alter plant cellular functions and successfully infect their hosts. We have generated a library of ORFs encoding putative G. rostochiensis putative apoplastic effectors in vectors for expression in planta. These clones were assessed for morphological and developmental effects on plants as well as their ability to induce or suppress plant defenses. Several CLAVATA3/ESR-like proteins induced developmental phenotypes, whereas predicted cell wall-modifying proteins induced necrosis and chlorosis, consistent with roles in cell fate alteration and tissue invasion, respectively. When directed to the apoplast with a signal peptide, two effectors, an ubiquitin extension protein (GrUBCEP12) and an expansin-like protein (GrEXPB2), suppressed defense responses including NB-LRR signaling induced in the cytoplasm. GrEXPB2 also elicited defense response in species- and sequence-specific manner. Our results are consistent with the scenario whereby potato cyst nematodes secrete effectors that modulate host cell fate and metabolism as well as modifying host cell walls. Furthermore, we show a novel role for an apoplastic expansin-like protein in suppressing intra-cellular defense responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.