ArticleLab on a chip2015
A versatile valving toolkit for automating fluidic operations in paper microfluidic devices.
Article in Lab on a chip, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Challenges in the development of microfluidic paper-based analytical devices (μPADs).Mikrochimica acta · 2025Review
- Artificial intelligence enhanced electrochemical immunoassay for staphylococcal enterotoxin B.Scientific reports · 2025Article
- Microfluidic paper analytic device (μPAD) technology for food safety applications.Biomicrofluidics · 2024Review
- Pneumatic computers for embedded control of microfluidics.Science advances · 2023Article
- Advanced trap lateral flow immunoassay sensor for the detection of cortisol in human bodily fluids.Scientific reports · 2021Article
- Systematic Review: Microfluidics and Plasmodium.Micromachines · 2021Review
- Capillary flow control in lateral flow assays via delaminating timers.Science advances · 2021Article
- Flow control in a laminate capillary-driven microfluidic device.The Analyst · 2021Article
- A New Paper-Based Microfluidic Device for Improved Detection of Nitrate in Water.Sensors (Basel, Switzerland) · 2020Article
- Hybrid 3D printed-paper microfluidics.Scientific reports · 2020Article
- Recent Advances of Fluid Manipulation Technologies in Microfluidic Paper-Based Analytical Devices (μPADs) toward Multi-Step Assays.Micromachines · 2020Review
- Integrated wax valve for robust fluid control in an electrochemical fabric-based device.Analytical methods : advancing methods and applications · 2019Article
- Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices.Molecules (Basel, Switzerland) · 2019Review
- A simple micropump based on a freeze-dried superabsorbent polymer for multiplex solution processing in disposable devices.Royal Society open science · 2019Article
- Emerging Point-of-care Technologies for Food Safety Analysis.Sensors (Basel, Switzerland) · 2019Review
- Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.Chemical reviews · 2019Review
- Geometric Flow Control Lateral Flow Immunoassay Devices (GFC-LFIDs): A New Dimension to Enhance Analytical Performance.Research (Washington, D.C.) · 2019Article
- A paper-based microfluidic platform with shape-memory-polymer-actuated fluid valves for automated multi-step immunoassays.Microsystems & nanoengineering · 2019Article
- Article
- Novel functionalities of hybrid paper-polymer centrifugal devices for assay performance enhancement.Biomicrofluidics · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Failure to utilize valving and automation techniques has restricted the complexity of fluidic operations that can be performed in paper microfluidic devices. We developed a toolkit of paper microfluidic valves and methods for automatic valve actuation using movable paper strips and fluid-triggered expanding elements. To the best of our knowledge, this is the first functional demonstration of this valving strategy in paper microfluidics. After introduction of fluids on devices, valves can actuate automatically after a) a certain period of time, or b) the passage of a certain volume of fluid. Timing of valve actuation can be tuned with greater than 8.5% accuracy by changing lengths of timing wicks, and we present timed on-valves, off-valves, and diversion (channel-switching) valves. The actuators require ~30 μl fluid to actuate and the time required to switch from one state to another ranges from ~5 s for short to ~50 s for longer wicks. For volume-metered actuation, the size of a metering pad can be adjusted to tune actuation volume, and we present two methods - both methods can achieve greater than 9% accuracy. Finally, we demonstrate the use of these valves in a device that conducts a multi-step assay for the detection of the malaria protein PfHRP2. Although slightly more complex than devices that do not have moving parts, this valving and automation toolkit considerably expands the capabilities of paper microfluidic devices. Components of this toolkit can be used to conduct arbitrarily complex, multi-step fluidic operations on paper-based devices, as demonstrated in the malaria assay device.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.