ArticleBiophysical journal2015
Irrelevance of the power stroke for the directionality, stopping force, and optimal efficiency of chemically driven molecular machines.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Chiral catalysis-driven rotary molecular motors.Nature chemistry · 2026Article
- What Determines the Directionality of Kinesins? Studying the Anomalous Directionality of Nonclaret Disjunctional Motor Mutants.Journal of the American Chemical Society · 2026Article
- Solvent-Driven Modulation of Shuttling Dynamics in an Autonomous Chemically Fueled Information Ratchet.The journal of physical chemistry. B · 2025Article
- An information ratchet improves selectivity in molecular recognition under non-equilibrium conditions.Nature nanotechnology · 2025Article
- Understanding hypertrophic cardiomyopathy and its regulation by myosin drugs.Protein science : a publication of the Protein Society · 2025Article
- Structural Influence of the Chemical Fueling System on a Catalysis-Driven Rotary Molecular Motor.Journal of the American Chemical Society · 2025Article
- Power Strokes in Molecular Motors: Predictive, Irrelevant, or Somewhere in Between?Journal of the American Chemical Society · 2025Article
- Article
- Conformational Changes and ATP Hydrolysis in Zika Helicase: The Molecular Basis of a Biomolecular Motor Unveiled by Multiscale Simulations.Journal of the American Chemical Society · 2023Article
- Non-equilibrium Steady States in Catalysis, Molecular Motors, and Supramolecular Materials: Why Networks and Language Matter.Journal of the American Chemical Society · 2023Review
- Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM.Structure (London, England : 1993) · 2023Review
- Information flow, gating, and energetics in dimeric molecular motors.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Using Catalysis to Drive Chemistry Away from Equilibrium: Relating Kinetic Asymmetry, Power Strokes, and the Curtin-Hammett Principle in Brownian Ratchets.Journal of the American Chemical Society · 2022Review
- Tuning the Force, Speed, and Efficiency of an Autonomous Chemically Fueled Information Ratchet.Journal of the American Chemical Society · 2022Article
- Transamidation-Driven Molecular Pumps.Journal of the American Chemical Society · 2022Article
- Insights from an information thermodynamics analysis of a synthetic molecular motor.Nature chemistry · 2022Article
- A chemical thermodynamic model of motor enzymes unifies chemical-Fx and powerstroke models.Biophysical journal · 2022Article
- Article
- A catalysis-driven artificial molecular pump.Nature · 2021Article
- Optimizing enzymatic catalysts for rapid turnover of substrates with low enzyme sequestration.Biological cybernetics · 2020Article
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Authors and funding
1 author.
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Abstract
A simple model for a chemically driven molecular walker shows that the elastic energy stored by the molecule and released during the conformational change known as the power-stroke (i.e., the free-energy difference between the pre- and post-power-stroke states) is irrelevant for determining the directionality, stopping force, and efficiency of the motor. Further, the apportionment of the dependence on the externally applied force between the forward and reverse rate constants of the power-stroke (or indeed among all rate constants) is irrelevant for determining the directionality, stopping force, and efficiency of the motor. Arguments based on the principle of microscopic reversibility demonstrate that this result is general for all chemically driven molecular machines, and even more broadly that the relative energies of the states of the motor have no role in determining the directionality, stopping force, or optimal efficiency of the machine. Instead, the directionality, stopping force, and optimal efficiency are determined solely by the relative heights of the energy barriers between the states. Molecular recognition--the ability of a molecular machine to discriminate between substrate and product depending on the state of the machine--is far more important for determining the intrinsic directionality and thermodynamics of chemo-mechanical coupling than are the details of the internal mechanical conformational motions of the machine. In contrast to the conclusions for chemical driving, a power-stroke is very important for the directionality and efficiency of light-driven molecular machines and for molecular machines driven by external modulation of thermodynamic parameters.
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