Evidence map›Paper›PMID 25606672›Full record

ReviewBiophysical journal2015

Molecular biophysics of Orai store-operated Ca2+ channels.

Anna Amcheslavsky, Mona L Wood, Andriy V Yeromin, Ian Parker, J Alfredo Freites, Douglas J Tobias, Michael D Cahalan

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
7.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 72 citations in OpenAlex.

  1. Review
  2. Article
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  7. Review
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  9. Review
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  12. Regulatory T cells suppress Th17 cell CaProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  13. KCells · 2020
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Dynamic CaCell calcium · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anna AmcheslavskyDepartment of Physiology and Biophysics, University of California at Irvine, Irvine, California.
Mona L WoodDepartment of Chemistry, University of California at Irvine, Irvine, California.
Andriy V YerominDepartment of Physiology and Biophysics, University of California at Irvine, Irvine, California.
Ian ParkerDepartment of Physiology and Biophysics, University of California at Irvine, Irvine, California; Department of Neurobiology and Behavior, University of California at Irvine, Irvine, California.
J Alfredo FreitesDepartment of Chemistry, University of California at Irvine, Irvine, California.
Douglas J TobiasDepartment of Chemistry, University of California at Irvine, Irvine, California.
Michael D CahalanDepartment of Physiology and Biophysics, University of California at Irvine, Irvine, California; Institute for Immunology, University of California at Irvine, Irvine, California. Electronic address: mcahalan@uci.edu.
University of California, Irvine · US

Funding

Molecular Mechanisms of lon Channels in T LymphocytesR01NS014609 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 1985 to 2022
$7.0M
Project 3: Structural Studies of Voltage-Gated Potassium Channels as FunctionP01GM086685 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BLASIE, J. KENT · 2009 to 2013
$6.7M
Elementary Events of Intracellular Calcium SignalingR37GM048071 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PARKER, IAN · 2011 to 2020
$5.3M
SPATIAL AND TEMPORAL ASPECTS OF INSP3 SIGNALLINGR01GM048071 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PARKER, IAN · 1992 to 2010
$3.9M
Molecular Mechanisms of Ion Channels in T LymphocytesR37NS014609 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2006 to 2012
$3.3M
Structure-based design of Hv1 proton channel blockers as potential anti-neoplastiF30CA171717 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI WOOD, MONA · 2013 to 2015
$119k
NCI NIH HHS F30 CA171717NCI NIH HHS F30CA171717NIGMS NIH HHS GM048071NIGMS NIH HHS GM86685NIGMS NIH HHS P01 GM086685NIGMS NIH HHS R01 GM048071NIGMS NIH HHS R37 GM048071NINDS NIH HHS NS14609NINDS NIH HHS R01 NS014609NINDS NIH HHS R37 NS014609
6 · The paper itself

Abstract

Upon endoplasmic reticulum Ca(2+) store depletion, Orai channels in the plasma membrane are activated directly by endoplasmic reticulum-resident STIM proteins to generate the Ca(2+)-selective, Ca(2+) release-activated Ca(2+) (CRAC) current. After the molecular identification of Orai, a plethora of functional and biochemical studies sought to compare Orai homologs, determine their stoichiometry, identify structural domains responsible for the biophysical fingerprint of the CRAC current, identify the physiological functions, and investigate Orai homologs as potential therapeutic targets. Subsequently, the solved crystal structure of Drosophila Orai (dOrai) substantiated many findings from structure-function studies, but also revealed an unexpected hexameric structure. In this review, we explore Orai channels as elucidated by functional and biochemical studies, analyze the dOrai crystal structure and its implications for Orai channel function, and present newly available information from molecular dynamics simulations that shed light on Orai channel gating and permeation.

Indexed as

Calcium SignalingIon Channel GatingAmino Acid SequenceAnimalsCalcium ChannelsHumansMolecular Sequence DataCalcium Channels

Identifiers

PMID25606672
PMCPMC4302196
OpenAlexW2169426597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.