ArticleJoints
Degenerative disease in rotator cuff tears: what are the biochemical and histological changes?
Article in Joints. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Single-row versus transosseous technique in the arthroscopic treatment of rotator cuff tears: a meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Pooled it
- Proteomic biomarkers in rotator cuff disease: Current evidence and translational implications from a systematic review and network analysis.Journal of orthopaedic translation · 2026Review
- Scapular morphology does not predict supraspinatus tendon tear propagation following an individualised exercise therapy programme.Journal of experimental orthopaedics · 2024Article
- Biomolecules Related to Rotator Cuff Pain: A Scoping Review.Biomolecules · 2022Article
- Arthroscopic therapy of rotator cuff diseases: A bibliometric study of the past 2 decades (2002-2021).Frontiers in surgery · 2022Article
- Anti-inflammatory and Tendon-Protective Effects of Adipose Stem Cell-Derived Exosomes with Concomitant Use of Glucocorticoids.Stem cells international · 2022Article
- Quantitative analysis of repaired rabbit supraspinatus tendons (± channeling) using magnetic resonance imaging at 7 Tesla.Quantitative imaging in medicine and surgery · 2021Article
- Family Predisposition for Rotator Cuff Tear and Other Tendinopathies - A Case-Control Study.Revista brasileira de ortopedia · 2020Article
- Spectrum of Tendon Pathologies: Triggers, Trails and End-State.International journal of molecular sciences · 2020Review
- Risk Factors for Rotator Cuff Disease: An Experimental Study on Intact Human Subscapularis Tendons.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Effect of Muscle Quality on Operative and Nonoperative Treatment of Rotator Cuff Tears.Orthopaedic journal of sports medicine · 2019Article
- The role of mechanobiology in progression of rotator cuff muscle atrophy and degeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Collagen I: a kingpin for rotator cuff tendon pathology.American journal of translational research · 2018Review
- Review
- Functional outcomes of traumatic and non-traumatic rotator cuff tears after arthroscopic repair.World journal of orthopedics · 2017Article
- Matrix Metalloproteases 1 and 3 Promoter Gene Polymorphism Is Associated With Rotator Cuff Tear.Clinical orthopaedics and related research · 2017Article
- Histological Evidence of Muscle Degeneration in Advanced Human Rotator Cuff Disease.The Journal of bone and joint surgery. American volume · 2017Article
- Alterations in tendon microenvironment in response to mechanical load: potential molecular targets for treatment strategies.American journal of translational research · 2017Review
- Muscle architectural changes after massive human rotator cuff tear.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Tendinopathy: Investigating the Intersection of Clinical and Animal Research to Identify Progress and Hurdles in the Field.JBJS reviews · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The histopathological changes associated with rotator cuff tears include thinning and disorganization of collagen fibers, the presence of granulation tissue, increased levels of glycosaminoglycans, fibrocartilaginous metaplasia, calcification, fatty infiltration, and necrosis of the tendon margin with cell apoptosis. The biochemical changes include an increase in the expression of matrix metalloproteinases (MMPs) and a decrease in tissue inhibitor of metalloproteinases (TIMP) messenger ribonucleic acid expression. Histological evidence of tendinopathy has been found in patients with rotator cuff tear. Biochemical changes include significant increases in MMP1, MMP2, MMP3, and in TIMP1 and TIMP2 levels, not only at the lateral supraspinatus edge, but also in the macroscopically intact portion of the supraspinatus tendon and in the intact subscapularis. The tissue in the ruptured area of the supraspinatus tendon undergoes marked rearrangement at molecular levels. This involves the activity of MMP1, 2, and 3 and supports a critical role of MMPs in tendon physiology. Intact parts of the torn supraspinatus tendon can present the histopathological changes associated with rotator cuff tears. These findings suggest that biochemical changes can already occur in a macroscopically intact tendon and seem to point to a global degenerative process in the shoulder.
Indexed as
Identifiers
25606538PMC4295662W2100861118What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.