Evidence map›Paper›PMID 25606458›Full record

ArticleMeta gene2014

Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meat.

Daniel Estanislao Goszczynski, Juliana Papaleo Mazzucco, María Verónica Ripoli, Edgardo Leopoldo Villarreal, Andrés Rogberg-Muñoz, Carlos Alberto Mezzadra, Lilia Magdalena Melucci, Guillermo Giovambattista

Open access · hybridAbstract read
In one paragraph

Article in Meta gene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Variation in theAnimals : an open access journal from MDPI · 2023
    Article
  3. Association analysis for SNPs ofAnimal biotechnology · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Daniel Estanislao GoszczynskiIGEVET, CCT LA PLATA CONICET, FCV, UNLP, La Plata B1900AVW, CC 296, Argentina ; Fellow of the Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Argentina.
Juliana Papaleo MazzuccoUnidad Integrada INTA Balcarce - FCA, UNMdP, Argentina.
María Verónica RipoliIGEVET, CCT LA PLATA CONICET, FCV, UNLP, La Plata B1900AVW, CC 296, Argentina.
Edgardo Leopoldo VillarrealUnidad Integrada INTA Balcarce - FCA, UNMdP, Argentina.
Andrés Rogberg-MuñozIGEVET, CCT LA PLATA CONICET, FCV, UNLP, La Plata B1900AVW, CC 296, Argentina.
Carlos Alberto MezzadraUnidad Integrada INTA Balcarce - FCA, UNMdP, Argentina.
Lilia Magdalena MelucciUnidad Integrada INTA Balcarce - FCA, UNMdP, Argentina.
Guillermo GiovambattistaIGEVET, CCT LA PLATA CONICET, FCV, UNLP, La Plata B1900AVW, CC 296, Argentina.
National University of Mar del Plata · ARConsejo Nacional de Investigaciones Científicas y Técnicas · ARInstituto de Genética Veterinaria · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LIPE is an intracellular neutral lipase, which is capable of hydrolyzing a variety of esters and plays a key role in the mobilization of fatty acids from diacylglycerols. The objectives of this study were to characterize the genetic polymorphism of bovine LIPE gene and to evaluate the possible association between three SNPs in the coding regions of this gene with the fatty acid composition of meat in a cattle population. Forty-three unrelated animals from different cattle breeds were re-sequenced and 21 SNPs were detected over approximately 2600 bp, five of these SNPs were novel. Three SNPs were selected, on the basis of evolutionary conservation, to perform validation and association studies in a crossbred cattle population. Our results may suggest a possible association of SNP1 with contents of oleic acid and total monounsaturated fatty acids (p < 0.01), and SNP2 and SNP3 with Heneicosylic acid content (p < 0.01), may be helpful to improve the quality of meat and improve health.

Indexed as

ALBP, adipocyte lipid binding proteinBovineC18:1c9, oleic acidC21:0, heneicosylic acidCt, C-terminalF1, first filialF2, second filialGNRHR, gonadotropin-releasing hormone receptorhe, unbiased expected heterozygosityho, observed heterozygosityHWE, Hardy–Weinberg equilibriumINTA, National Institute of Agricultural TechnologyLIPELIPE, hormone-sensitive lipaseLipid contentMUFA, total monounsaturated fatty acidsn, number of samplesNt, N-terminalpb, base pairsPCR, polymerase chain reactionPolymorphismp, p-valueR, regulatory moduleSNP, single nucleotide polymorphism

Identifiers

PMID25606458
PMCPMC4287880
OpenAlexW2070025758

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.