ArticleMeta gene2014
Association of the rs11196218 polymorphism in TCF7L2 with type 2 diabetes mellitus in Asian population.
Article in Meta gene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Type 2 Diabetes Mellitus Is Associated with the Risk of Cognitive Impairment: a Meta-Analysis.Journal of molecular neuroscience : MN · 2019Pooled it
- Association of the Transcription Factor 7 Like 2 (TCF7L2) Polymorphism With Diabetic Nephropathy Risk: A Meta-Analysis.Medicine · 2016Pooled it
- The association between the rs11196218A/G polymorphism of the TCF7L2 gene and type 2 diabetes in the Chinese Han population: a meta-analysis.Clinics (Sao Paulo, Brazil) · 2015Pooled it
- Cost-consequence analysis of a digital health-enabled non-communicable disease management intervention in Ghana.Cost effectiveness and resource allocation : C/E · 2026Article
- Understanding the Genetic Landscape of Gestational Diabetes: Insights into the Causes and Consequences of Elevated Glucose Levels in Pregnancy.Metabolites · 2024Review
- Inhibitory Effect of TCF7L2 on Pancreatic β-Cell Dedifferentiation via ERK/MAPK Signaling Pathway in Diabetes.Clinical medicine insights. Endocrinology and diabetes · 2024Article
- Genetic risk factors associated with gestational diabetes in a multi-ethnic population.PloS one · 2021Article
- Associations of TCF7L2 rs11196218 (A/G) and GLP-1R rs761386 (C/T) Gene Polymorphisms with Obesity in Chinese Population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Role of GNB3, NET, KCNJ11, TCF7L2 and GRL genes single nucleotide polymorphism in the risk prediction of type 2 diabetes mellitus.3 Biotech · 2016Review
- Polymorphisms in TCF7L2 gene are associated with gestational diabetes mellitus in Chinese Han population.Scientific reports · 2016Article
- Article
- Assay method for quality control and stability studies of a new anti-diabetic and anti-dyslipidemic flavone (S002-853).Pharmacognosy magazine · 2015Article
- Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities.Drug design, development and therapy · 2015Article
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo clarify the association of rs11196218 polymorphism in transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in Asian population by a case-control study and meta-analysis.
methodsIn the case-control study, 1842 patients with T2DM and 7777 normal glucose-tolerant controls in the Henan province of China were genotyped for rs11196218 in TCF7L2 by PCR-ligase detection reaction. We used allele, co-dominant, dominant and recessive models to evaluate the risk association and performed a meta-analysis of the results of different genetic models in previous studies and the current study.
resultsThe AG genotype of rs11196218 was associated with risk of T2DM in the Henan population (odds ratio 1.37, 95% confidence interval 1.06-1.78), and dominant model showed marginal significant association (1.28, 0.99-1.67). Meta-analysis of 10 studies revealed the dominant model associated with T2DM in the overall population (1.20, 1.05-1.36). When stratified by region (southern and northern China and Japan), both the AG genotype and the dominant model were associated with risk of T2DM in southern Chinese (1.31, 1.03-1.66; 1.27, 1.01-1.60, respectively).
conclusionThe rs11196218 polymorphism in TCF7L2 is associated with risk of T2DM in Asian population.
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