Evidence map›Paper›PMID 25606411›Full record

ArticleMeta gene2014

PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity in Latvians, Lithuanians and Taiwanese.

Tatjana Sjakste, Natalia Paramonova, Lawrence Shi-Shin Wu, Zivile Zemeckiene, Brigita Sitkauskiene, Raimundas Sakalauskas, Jiu-Yao Wang, Nikolajs Sjakste

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Article in Meta gene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Genetic variations in theExperimental and therapeutic medicine · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tatjana SjaksteGenomics and Bioinformatics, Institute of Biology of the University of Latvia, Miera str. 3, LV2169, Salaspils, Latvia.
Natalia ParamonovaGenomics and Bioinformatics, Institute of Biology of the University of Latvia, Miera str. 3, LV2169, Salaspils, Latvia.
Lawrence Shi-Shin WuInstitute of Biomedicine, Tzu-Chi University, Tzu-Chi, Taiwan.
Zivile ZemeckieneDepartment of Laboratory Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Brigita SitkauskieneDepartment of Pulmonology and Immunology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Raimundas SakalauskasDepartment of Pulmonology and Immunology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Jiu-Yao WangDivision of Allergy and Clinical Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Nikolajs SjaksteFaculty of Medicine, University of Latvia, Riga, Latvia ; Latvian Institute of Organic Synthesis, Riga, Latvia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity was investigated in 1438 unrelated subjects from Latvia, Lithuania and Taiwan. In general, polymorphism of each individual locus showed tendencies similar to determined previously in HapMap populations. Main differences concern Taiwanese and include presence of rs2277460 rare allele A not found before in Asians and absence of rs2295827 rare alleles homozygotes TT observed in all other human populations. Observed patterns of SNPs and haplotype diversity were compatible with expectation of neutral model of evolution. Linkage disequilibrium between the rs2295826 and rs2295827 was detected to be complete in Latvians and Lithuanians (D´ = 1; r(2) = 1) and slightly disrupted in Taiwanese (D´ = 0.978; r(2) = 0.901). Population differentiation (FST statistics) was estimated from pairwise population comparisons of loci variability, five locus haplotypes and PSMA6 and PSMC6 two locus haplotypes. Latvians were significantly different from all Asians at each of 5 SNPs and from Lithuanians at the rs1048990 and PSMC6 loci. Lithuanian and Asian populations exhibited similarities at the PSMC6 loci and were different at the PSMA6 and PSMA3 SNPs. Considering five locus haplotypes all European populations were significantly different from Asian; Lithuanian population was different from both Latvian and CEU. Allele specific patterns of transcription factor binding sites and splicing signals were predicted in silico and addressed to eventual functionality of nucleotide substitutions and their potential to be involved in human genome evolution and geographical adaptation. Current study represents a novel step toward a systematic analysis of the proteasomal gene genetic diversity in human populations.

Indexed as

Genetic diversityHapMap-CEU, NorthWestern EuropeansHapMap HCB, Han ChineseHapMap JPT, JapaneseHuman populationHWE, Hardy–Weinberg equilibriumLD, linkage disequilibriumLT, Lithuanian populationLV, Latvian populationProteasomePSMA3PSMA6PSMC6SNPSNP, single nucleotide polymorphismT2DM, type 2 diabetes mellitusTFBS, transcription factor binding siteTF, transcription factorTW, Taiwanese populationUPS, ubiquitin–proteasome system

Identifiers

PMID25606411
PMCPMC4287955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.