Evidence map›Paper›PMID 25606379›Full record

ArticleMeta gene2013

Effect of PON1 gene polymorphisms in Turkish patients with hepatocellular carcinoma.

Hikmet Akkız, Sedef Kuran, Ersin Akgöllü, Oğuz Üsküdar, Aynur Bekar, Süleyman Bayram, Selçuk Yıldırım, Yakup Ülger, Berrin Yalınbaş Kaya, Mahmut Şansal and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Meta gene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hikmet AkkızÇukurova University, Faculty of Medicine, Department of Gastroenterology, 01330 Adana, Turkey.
Sedef KuranÇukurova University, Faculty of Medicine, Department of Gastroenterology, 01330 Adana, Turkey.
Ersin AkgöllüÇukurova University, Faculty of Medicine, Department of Gastroenterology, 01330 Adana, Turkey.
Oğuz ÜsküdarÇukurova University, Faculty of Medicine, Department of Gastroenterology, 01330 Adana, Turkey.
Aynur BekarÇukurova University, Faculty of Medicine, Department of Gastroenterology, 01330 Adana, Turkey.
Süleyman BayramAdıyaman University, Adıyaman School of Health, Department of Nursing, 02040 Adıyaman, Turkey.
Selçuk YıldırımÇukurova University, Faculty of Medicine, Department of Gastroenterology, 01330 Adana, Turkey.
Yakup ÜlgerÇukurova University, Faculty of Medicine, Department of Gastroenterology, 01330 Adana, Turkey.
Berrin Yalınbaş KayaÇukurova University, Faculty of Medicine, Department of Gastroenterology, 01330 Adana, Turkey.
Mahmut ŞansalÇukurova University, Faculty of Medicine, Department of Gastroenterology, 01330 Adana, Turkey.
Ercan ÇınarBatman University, Arts & Science Faculty, Chemistry Department (Biochemistry Division), Batman, Turkey.
Cukurova University · TRAdıyaman University · TRBatman University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReactive oxygen species (ROS) can oxidize biological molecules that mediate carcinogenesis by causing metabolic malfunction and damage to DNA. Human serum paraoxonases (PON1, PON2 and PON3) play a role in antioxidant defense and protect the cell against ROS. PON1 polymorphisms Q192R and L55M have been shown to be associated with several human cancers, but their association with hepatocellular carcinoma (HCC) has yet to be investigated.

methodsWe performed genotyping analysis using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay in a hospital-based case-control study of 217 confirmed HCC patients and 217 age-, gender-, smoking- and alcohol consumption-matched cancer-free controls in Turkish population.

resultsQ192R and L55M polymorphisms were in significant linkage disequilibrium (LD) (D' = 0.77). However, allele, genotype and haplotype analysis showed no significant differences between the risks of HCC and PON1 polymorphisms. Moreover, no significant differences were found between clinical findings, clinicopathological features and sex in comparison with the PON1 genotypes in HCC group.

conclusionOur results suggest for the first time that neither the Q192R polymorphism nor the L55M polymorphism has relationship with the risk of developing HCC. Further independent studies are required to clarify the possible role of PON1 gene Q192R and L55M polymorphisms on the risk of developing HCC in a larger series and also in patients of different ethnic origins.

Indexed as

Genetic susceptibilityHepatitis B virusHepatocellular carcinomaPON1 gene Q192R and L55M polymorphisms

Identifiers

PMID25606379
PMCPMC4205027
OpenAlexW2021997425

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.