ArticleJournal of lasers in medical sciences2014
The disinfecting efficacy of root canals with laser photodynamic therapy.
Article in Journal of lasers in medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Effectiveness of ultrasonically activated irrigation on root canal disinfection: a systematic review of in vitro studies.Clinical oral investigations · 2018Pooled it
- Efficacy of indocyanine green-mediated photodynamic therapy in the treatment of Candida albicans-penetrated denture base material: an in vitro study.BMC oral health · 2026Article
- Antimicrobial activity of Nd: YAG irradiation, laser activated photodynamic therapy and passive ultrasonic irrigation on enterococcus faecalis biofilms (an ex vivo study).BMC oral health · 2026Article
- A comprehensive review on advancements in laser-assisted dental treatments: focus on minimally invasive techniques and clinical outcomes.Lasers in medical science · 2025Review
- Evaluation of the Root and Canal Morphology of Maxillary and Mandibular Premolars in an Emirati Sub-Population.International dental journal · 2025Article
- Conservative Management of Dens Invaginatus Type IIIb Using Photodynamic Therapy: A Case Report.Iranian endodontic journal · 2025Article
- A 980 nm Diode Laser as an Adjunctive Therapy on the Healing of Apical Periodontitis Following Endodontic Retreatment: A Randomized Controlled Clinical Trial Study.Journal of lasers in medical sciences · 2024Article
- Comparison between three methods of diode laser 810 nm, photodynamic therapy with laser 660 nm, and hypochlorite solution for disinfection of pulp canal of primary teeth.Dental research journal · 2024Article
- Effectiveness of Different Final Irrigation Procedures onMaterials (Basel, Switzerland) · 2022Article
- Antimicrobial action of ozonated water and photodynamic therapy with sonic activation in root canals infected withJournal of clinical and experimental dentistry · 2022Article
- Investigating the Antibacterial Effect of Passive Ultrasonic Irrigation, Photodynamic Therapy and Their Combination on Root Canal Disinfection.Journal of lasers in medical sciences · 2021Article
- Electrochemical Disinfection of Experimentally Infected Teeth by Boron-Doped Diamond Electrode Treatment.Journal of clinical medicine · 2019Article
- Survival rates of teeth treated with bacterial photo-dynamic therapy during disinfection of the root canal system.British dental journal · 2019Article
- Update of the therapeutic planning of irrigation and intracanal medication in root canal treatment. A literature review.Journal of clinical and experimental dentistry · 2019Review
- Formulation and characterization of chlorhexidine HCl nanoemulsion as a promising antibacterial root canal irrigant: in-vitro and ex-vivo studies.International journal of nanomedicine · 2019Article
- Antimicrobial photodynamic therapy-a promising treatment for prosthetic joint infections.Lasers in medical science · 2018Article
- Effectiveness of repeated photodynamic therapy in the elimination of intracanal Enterococcus faecalis biofilm: an in vitro study.Lasers in medical science · 2017Article
- Comparison of the Antimicrobial Efficacy of Calcium Hydroxide and Photodynamic Therapy AgainstJournal of lasers in medical sciences · 2017Article
- Comparison between one-session root canal treatment with aPDT and two-session treatment with calcium hydroxide-based antibacterial dressing, in dog's teeth with apical periodontitis.Lasers in medical science · 2016Article
- In vivo model for microbial invasion of tooth root dentinal tubules.Journal of applied oral science : revista FOB · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInfecting microorganisms of the root canals are difficult to eliminate during endodontic treatment. In this study the effect of root canal disinfection with photodynamic therapy (PDT) at different time intervals in comparison to 2.5% sodium hypochlorite (NaOCl) irrigation and passive ultrasonic irrigation (PUI) in extracted teeth colonized with Enterococcus faecalis and Candida albicans was tested to assess which treatment reaches the best disinfection rate.
methodsOne hundred and fifty-six extracted single-rooted teeth were collected, sterilized, and incubated with Enterococcus faecalis (ATCC 29212) and Candida albicans (ATCC 60193). The two groups were further divided into 6 groups depending on the treatment mode; HELBO(®)Endo Blue photosensitizer dye application followed by HELBO laser irradiation, with the output power 100 mW and emission of 660 nm, for a 1, 3 and 5 minutes, irrigation with 2.5% NaOCl, 10 second PUI with 2.5% NaOCl and control group. Flow cytometry and scanning electron microscopic (SEM) analysis were used to determine the effectiveness of the different disinfecting methods.
resultsThe different disinfecting methods had a significantly different effect on the percent of dead cells (p<0.001). A statistical significance of dead cells between organisms (p<0.001) was observed. Interaction between the disinfecting method and both of organisms had shown the statistical significance (p=0.045). Percent of dead cells in treatment groups were significantly higher compared to control group for both organisms (p<0.001).
conclusionsPUI still remains the most effective method for disinfection of infected root canals in endodontics compared to hand instrumentation for both microorganisms. SEM analysis only confirmed the results. Other results ex vivo suggested that prolonging the time from 1 to 5 minutes of PDT increased the number of killed microorganisms significantly, therefore longer times of photodynamic therapy were recommended. Irrigation with 2.5% NaOCl showed similar results to 5 min irradiation.
Indexed as
Identifiers
25606335PMC4290519W2140521174What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.