Evidence map›Paper›PMID 25606321›Full record

ArticleJournal of lasers in medical sciences2013

Photothrombosis of corneal neovascularization by photodynamic therapy utilizing verteporfin and diode laser.

Aziza Ahmed Hassan, Dina Foad Ghoneim, Amr Abdelraheem El-Dib, Salwa Abdelkawi Ahmed, Ahmed Medhat Abdel-Salam

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of lasers in medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Contact Lens-related Complications: A Review.Journal of ophthalmic & vision research
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aziza Ahmed HassanOphthalmic Department, National Institute of Laser Enhanced Science, Cairo University, Egypt.
Dina Foad GhoneimOphthalmic Department, National Institute of Laser Enhanced Science, Cairo University, Egypt.
Amr Abdelraheem El-DibOphthalmic Department, National Institute of Laser Enhanced Science, Cairo University, Egypt.
Salwa Abdelkawi AhmedDepartment of Vision Science, Biophysics and Laser Science Unit, Research Institute of Ophthalmology, Giza, Egypt.
Ahmed Medhat Abdel-SalamOphthalmic Department, National Institute of Laser Enhanced Science, Cairo University, Egypt.
Research Institute of Ophthalmology · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of the present study was to evaluate the effect of photodynamic therapy in the treatment of experimental corneal neovascularization (NV) with benzoporphyrin derivative (BPD).

methodsOne group was considered as control (n=6 eyes) then, corneal NV was induced in 30 New Zealand male rabbits (n=60 eyes) by placing 7.0 silk sutures at midstromal depth approximately1mm from the limbus. Fifteen rabbits with corneal NV were left without any treatment, and 15 rabbits were subjected to photodynamic therapy (PDT) by intravenous injection with Verteporfin at a dose of 1.5 mg /Kg. Diode laser (660 nm) was applied after 15 minutes for 5 minutes with a power of 50 mW/cm2. All rabbits were successively followed up by slit lamp examination for periods of 1 day, 1, 2, 3 and 4 weeks. Three rabbits were selected and sacrificed weekly (n=6 eyes each) and the corneas were isolated for histopathological examination.

resultsThe results of slit lamp examination indicated the gradual regression of the cornea neovascularization 4 weeks of PDT. Furthermore, regression of corneal neovascularization was documented clinically by decrease number and length of blood vessels and by histopathological examination.

conclusionPDT with Verteporfin can provide efficacious treatment of corneal neovascularization.

Indexed as

corneal neovascularizationsdiode laserphotodynamic therapy

Identifiers

PMID25606321
PMCPMC4295361
OpenAlexW2187856319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.