ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2015
ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells.
Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Role of MAPK Pathways in the Pathogenesis of Vitiligo.Current issues in molecular biology · 2026Review
- A novel role of erythropoietin in skin pigmentation through melanin production.Scientific reports · 2026Article
- Anti-melanogenic effects of Medicago sativa seed extracts on melanocytes.International journal of cosmetic science · 2025Article
- Soyasaponin-I Attenuates Melanogenesis through Activation of ERK and Suppression of PKA/CREB Signaling Pathways.ACS omega · 2025Article
- Physicochemical Characterization, Skin Penetration, Anti-Melanogenesis and Safety Assessment of Flavokawain C Nanofibers.International journal of molecular sciences · 2025Article
- Marine-Derived Bioactive Ingredients in Functional Foods for Aging: Nutritional and Therapeutic Perspectives.Marine drugs · 2024Review
- Anti-Melanogenic Effects of a Polysaccharide Isolated fromInternational journal of molecular sciences · 2024Article
- Ligularia fischeri ethanol extract: An inhibitor of alpha-melanocyte-stimulating hormone-stimulated melanogenesis in B16F10 melanoma cells.Journal of cosmetic dermatology · 2023Article
- Multivariate Analysis Revealed Ultrasonic-Assisted Extraction Improves Anti-Melanoma Activity of Non-Flavonoid Compounds in Indonesian Brown Algae Ethanol Extract.Molecules (Basel, Switzerland) · 2022Article
- Seaweed-Based Molecules and Their Potential Biological Activities: An Eco-Sustainable Cosmetics.Molecules (Basel, Switzerland) · 2021Review
- In Vitro Antitumor Potential of Sulfated Polysaccharides from Seaweed Caulerpa cupressoides var. flabellata.Marine biotechnology (New York, N.Y.) · 2021Article
- Anti-Melanogenic Effects of Ethanol Extracts of the Leaves and Roots ofMolecules (Basel, Switzerland) · 2020Article
- Potential Use of Seaweed Bioactive Compounds in Skincare-A Review.Marine drugs · 2019Review
- Article
- Beneficial Effects of Marine Algae-Derived Carbohydrates for Skin Health.Marine drugs · 2018Review
- Evaluation of Antioxidant and Anti-Melanogenic Activity of Different Extracts of Aerial Parts ofIranian journal of pharmaceutical research : IJPR · 2018Article
- Effects of Extremely Low Frequency Electromagnetic Fields on Melanogenesis through p-ERK and p-SAPK/JNK Pathways in Human Melanocytes.International journal of molecular sciences · 2017Article
- Hypopigmenting Effects of Brown Algae-Derived Phytochemicals: A Review on Molecular Mechanisms.Marine drugs · 2017Review
- Melanoma and brown seaweed: an integrative hypothesis.Journal of applied phycology · 2017Article
- Influence of plasma-activated compounds on melanogenesis and tyrosinase activity.Scientific reports · 2016Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeophyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible treatment for hyperpigmentation is not fully understood. This study investigated the effects of fucoidan on melanogenesis and related signaling pathways using Mel-Ab cells. Fucoidan significantly decreased melanin content. While fucoidan treatment decreased tyrosinase activity, it did not do so directly. Western blot analysis indicated that fucoidan downregulated microphthalmia-associated transcription factor and reduced tyrosinase protein expression. Further investigation showed that fucoidan activated the extracellular signal-regulated kinase (ERK) pathway, suggesting a possible mechanism for the inhibition of melanin synthesis. Treatment with PD98059, a specific ERK inhibitor, resulted in the recovery of melanin production. Taken together, these findings suggest that fucoidan inhibits melanogenesis via ERK phosphorylation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.