ArticleSexually transmitted infections2015
Population and dyadic-based seroincidence of herpes simplex virus-2 and syphilis in southern India.
Article in Sexually transmitted infections, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Herpes simplex virus: global infection prevalence and incidence estimates, 2016.Bulletin of the World Health Organization · 2020Pooled it
- Life Course Vaccination Continuum (LCVAC): An Expert Consensus on Life Course Vaccination in India.Cureus · 2026Review
- A Contemporary Insight Into the Seroepidemiology of Herpes Simplex Virus Infection in the Sub-Himalayan Region: Seroepidemiology of HSV Infection in North India.TheScientificWorldJournal · 2025Article
- Couples-based health behavior change interventions: A relationship science perspective on the unique opportunities and challenges to improve dyadic health.Comprehensive psychoneuroendocrinology · 2024Article
- Herpes simplex virus keratitis: electronic medical records driven big data analytics report from a tertiary eye institute of South India.International ophthalmology · 2023Article
- Control of sexually transmitted infections and global elimination targets, South-East Asia Region.Bulletin of the World Health Organization · 2021Review
- siRNA intervention inhibiting viral replication and delivery strategies for treating herpes simplex viral infection.Virusdisease · 2019Article
- The Prevalence of Syphilis Infection and Its Associated Factors in the General Population of Rwanda: A National Household-Based Survey.Journal of sexually transmitted diseases · 2016Article
- Syphilis: Is it Back with a Bang?Indian dermatology online journalArticle
Corrections and comments
- Erratum issuedCorrection.2018
Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
Abstract
objectivesHerpes simplex virus-2 (HSV-2) and syphilis are associated with increased risk of HIV, highlighting the importance of understanding their transmission dynamics. In India, most studies of HSV-2 and syphilis incidence are in high-risk populations and may not accurately reflect infectious activity. In this study, we aim to define HSV-2/syphilis incidence and risk factors in a population sample.
methodsWe conducted a longitudinal population-based survey in Andhra Pradesh, India, in two rounds: 2004-2005 and 2010-2011. Sociodemographic and behavioural data were collected, and dried blood spots tested for HSV-2 and Treponema pallidum IgG. After calculating sexually transmitted infection (STI) incidence, associated factors were assessed using modified Poisson regression and within-couple transmission rates modelled using seroconcordance/discordance data.
results12,617 adults participated at baseline with 8494 at follow-up. Incidence of HSV-2 and syphilis per 1000 person-years was 25.6 (95% CI 24.1 to 27.2) and 3.00 (95% CI 2.52 to 3.54). Incidence of HSV-2 was higher in women vs. men (31.1 vs. 20.2) and in rural vs urban residents (31.1 vs 19.0) (p<0.05 for both). STI seroincidence increased in a step-wise fashion with age and was associated with spousal seropositivity for both sexes (incidence rate ratio (IRR) 2.59 to 6.78). Within couples the rate of transmission per 1000 couple-years from men to women vs. women to men was higher for HSV-2 (193.3 vs. 119.0) compared with syphilis (27.6 vs. 198.8), p<0.05 for both.
conclusionsHSV-2 has higher incidence among subpopulations such as women, rural residents and older-aged individuals, suggesting a need for more generalised STI prevention approaches among populations traditionally considered low risk.
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