ArticleProceedings of the National Academy of Sciences of the United States of America2015
Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Discovering a low-dimensional temperature control architecture across animals.Scientific reports · 2026Article
- Bringing environment back into human evolution: why human genetics needs genome-environment association studies.Human genetics · 2026Review
- Comparative analysis of naked mole-rat thermogenesis and its potential to maintain euthermia in response to cold.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Brown adipose tissue inactivation exacerbates alcohol-induced liver steatosis, inflammation, and fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
- Molecular mediators of cold adaptation in mammalian cells.Communications biology · 2025Review
- Mitochondrial proteomic adaptations to daily torpor in the Djungarian hamster (Phodopus sungorus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- No UCP1 in the kidney.Molecular metabolism · 2025Article
- Neural control of fluid homeostasis is engaged below 10°C in hibernation.Current biology : CB · 2024Article
- Review
- Cold-induced suspension and resetting of CaiScience · 2023Article
- Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis.Nature communications · 2023Article
- Uncoupling protein 1-driven Cre (bioRxiv : the preprint server for biology · 2023Article
- Unexpected expression of heat-activated transient receptor potential (TRP) channels in winter torpid bats and cold-activated TRP channels in summer active bats.Zoological research · 2022Article
- A bioactive fraction of3 Biotech · 2021Article
- Protein Deimination Signatures in Plasma and Plasma-EVs and Protein Deimination in the Brain Vasculature in a Rat Model of Pre-Motor Parkinson's Disease.International journal of molecular sciences · 2020Article
- Conditional knockout of kisspeptin signaling in brown adipose tissue increases metabolic rate and body temperature and lowers body weight.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Bone marrow adipose tissue does not express UCP1 during development or adrenergic-induced remodeling.Scientific reports · 2019Article
- A dual Ucp1 reporter mouse model for imaging and quantitation of brown and brite fat recruitment.Molecular metabolism · 2019Article
- Article
- Somatosensory Neurons Enter a State of Altered Excitability during Hibernation.Current biology : CB · 2018Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Hibernating mammals possess a unique ability to reduce their body temperature to ambient levels, which can be as low as -2.9 °C, by active down-regulation of metabolism. Despite such a depressed physiologic phenotype, hibernators still maintain activity in their nervous systems, as evidenced by their continued sensitivity to auditory, tactile, and thermal stimulation. The molecular mechanisms that underlie this adaptation remain unknown. We report, using differential transcriptomics alongside immunohistologic and biochemical analyses, that neurons from thirteen-lined ground squirrels (Ictidomys tridecemlineatus) express mitochondrial uncoupling protein 1 (UCP1). The expression changes seasonally, with higher expression during hibernation compared with the summer active state. Functional and pharmacologic analyses show that squirrel UCP1 acts as the typical thermogenic protein in vitro. Accordingly, we found that mitochondria isolated from torpid squirrel brain show a high level of palmitate-induced uncoupling. Furthermore, torpid squirrels during the hibernation season keep their brain temperature significantly elevated above ambient temperature and that of the rest of the body, including brown adipose tissue. Together, our findings suggest that UCP1 contributes to local thermogenesis in the squirrel brain, and thus supports nervous tissue function at low body temperature during hibernation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.