ArticleProceedings of the National Academy of Sciences of the United States of America2015
Combating pertussis resurgence: One booster vaccination schedule does not fit all.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Maternal pertussis immunization and the blunting of routine vaccine effectiveness: a meta-analysis and modeling study.Nature communications · 2024Pooled it
- Acellular pertussis vaccines effectiveness over time: A systematic review, meta-analysis and modeling study.PloS one · 2018Pooled it
- Quantifying the impact of vaccination on pertussis dynamics in Sweden.PLoS computational biology · 2026Article
- Reply: Response to Pertussis in the Post-COVID-19 Era: Resurgence, Diagnosis, and Management.Infection & chemotherapy · 2025Article
- Pertussis vaccines, epidemiology and evolution.Nature reviews. Microbiology · 2024Review
- Disentangling the causes of mumps reemergence in the United States.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Optimal non-pharmaceutical intervention policy for Covid-19 epidemic via neuroevolution algorithm.Evolution, medicine, and public health · 2022Article
- Transmission dynamics reveal the impracticality of COVID-19 herd immunity strategies.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- COVID-19 herd immunity strategies: walking an elusive and dangerous tightrope.medRxiv : the preprint server for health sciences · 2020Article
- Detecting critical slowing down in high-dimensional epidemiological systems.PLoS computational biology · 2020Article
- Delay in booster schedule as a control parameter in vaccination dynamics.Journal of mathematical biology · 2019Article
- Projecting social contact matrices to different demographic structures.PLoS computational biology · 2018Article
- The impact of past vaccination coverage and immunity on pertussis resurgence.Science translational medicine · 2018Article
- Use of a 40-day rolling incidence to monitor pertussis in Nova Scotia, 2015.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2017Article
- Forecasting Epidemiological Consequences of Maternal Immunization.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Effectiveness of pertussis vaccination and duration of immunity.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016Article
- Using age-stratified incidence data to examine the transmission consequences of pertussis vaccination.Epidemics · 2016Article
- Pertussis: Microbiology, Disease, Treatment, and Prevention.Clinical microbiology reviews · 2016Review
- Pertussis immunity and epidemiology: mode and duration of vaccine-induced immunity.Parasitology · 2016Article
- Hand, Foot, and Mouth Disease in China: Critical Community Size and Spatial Vaccination Strategies.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Pertussis has reemerged as a major public health concern in many countries where it was once considered well controlled. Although the mechanisms responsible for continued pertussis circulation and resurgence remain elusive and contentious, many countries have nevertheless recommended booster vaccinations, the timing and number of which vary widely. Here, using a stochastic, age-stratified transmission model, we searched for cost-effective booster vaccination strategies using a genetic algorithm. We did so assuming four hypothesized mechanisms underpinning contemporary pertussis epidemiology: (I) insufficient coverage, (II) frequent primary vaccine failure, (III) waning of vaccine-derived protection, and (IV) vaccine "leakiness." For scenarios I-IV, successful booster strategies were identified and varied considerably by mechanism. Especially notable is the inability of booster schedules to alleviate resurgence when vaccines are leaky. Critically, our findings argue that the ultimate effectiveness of vaccine booster schedules will likely depend on correctly pinpointing the causes of resurgence, with misdiagnosis of the problem epidemiologically ineffective and economically costly.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.