Evidence map›Paper›PMID 25605856›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015

RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation.

Beryl McCormick, Kathryn Winter, Clifford Hudis, Henry Mark Kuerer, Eileen Rakovitch, Barbara L Smith, Nour Sneige, Jennifer Moughan, Amit Shah, Isabelle Germain and 11 more

Erratum issued Registry-linked trialOpen access · bronzeAbstract readClinical Trial, Phase IIIComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT00003857 (Phase III Trial of Tamoxifen Alone vs. Tamoxifen Plus Radiation Therapy for Good Risk Duct Carcinoma In-Situ), which is not on this map. Cited by 143 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 7 pooled it
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00003857 phase3completednot on this map

Phase III Trial of Tamoxifen Alone vs. Tamoxifen Plus Radiation Therapy for Good Risk Duct Carcinoma In-Situ (DCIS) of the Female Breast

TypeinterventionalSponsorRadiation Therapy Oncology GroupRan1999 to 2022Enrolled636ConditionsBreast CancerArmstamoxifen citrate, adjuvant therapy, radiation therapy
3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 7 syntheses or guidelines pooled it, 391 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Evidence-based guidelines for hypofractionated radiation in breast cancer: conclusions of the Catalan expert working group.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Pooled it
  4. Guideline
  5. Guideline
  6. DEGRO practical guidelines: radiotherapy of breast cancer II: radiotherapy of non-invasive neoplasia of the breast.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014
    Guideline
  7. Guideline
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Surgical Excision Without Radiation for Ductal Carcinoma in Situ of the Breast: 12-Year Results From the ECOG-ACRIN E5194 Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015
    Trial
  14. Headwinds in Breast Cancer Research: The Case for Pragmatic Radiotherapy De-escalation Studies.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Surgical management of breast cancer: a review.Annals of medicine and surgery (2012) · 2025
    Review
  19. Article
  20. Article

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 1 institution in 1 country.

Beryl McCormickBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada. mccormib@mskcc.org.
Kathryn WinterBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Clifford HudisBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Henry Mark KuererBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Eileen RakovitchBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Barbara L SmithBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Nour SneigeBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Jennifer MoughanBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Amit ShahBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Isabelle GermainBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Alan C HartfordBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Afshin RashtianBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Eleanor M WalkerBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Albert YuenBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Eric A StromBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Jeannette L WilcoxBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Laura A VallowBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
William SmallBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Anthony T PuBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Kevin KerlinBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
Julia WhiteBeryl McCormick and Clifford Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; Kathryn Winter and Jennifer Moughan, Radiation Therapy Oncology Group Statistical Center, Philadelphia; Amit Shah, York Cancer Center, York; Albert Yuen, Reading Hospital and Medical Center, Reading, PA; Henry Mark Kuerer, Nour Sneige, and Eric A. Strom, The University of Texas MD Anderson Cancer Center, Houston, TX; Barbara L. Smith, Massachusetts General Hospital, Boston, MA; Alan C. Hartford, Dartmouth Hitchcock Medical Center, Lebanon, NH; Afshin Rashtian, University of Southern California, Los Angeles, Los Angeles; Anthony T. Pu, Radiological Associates of Sacramento, Sacramento, CA; Eleanor M. Walker, Henry Ford Hospital, Detroit, MI; Jeannette L. Wilcox, Greenville SC Community Clinical Oncology Program (CCOP), Greenville, SC; Laura A. Vallow, Mayo Clinic, Jacksonville, FL; William Small Jr, Northwestern University Feinberg School of Medicine, Chicago, IL; Kevin Kerlin, Southeast Cancer Control Consortium CCOP, Winston-Salem, NC; Julia White, James Cancer Hospital, Ohio State University, Columbus, OH; Eileen Rakovitch, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; and Isabelle Germain, L'Hotel-Dieu de Quebec, Quebec, Quebec, Canada.
WinnMed · US

Funding

NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8M
RTOG Foreign AccrualU10CA021661 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI CURRAN, WALTER J. · 1985 to 2013
$150.3M
Statistics CoreU10CA180822 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Elaina Harper · 2014 to 2026
$146.4M
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
RTOG Foreign AccrualsU10CA037422 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI BRUNER, DEBORAH WATKINS · 1985 to 2013
$30.4M
OSU as Network Lead Academic Participating Site for the NCI NCTNU10CA180850 · NCI · OHIO STATE UNIVERSITY · PI BLUM, KRISTIE A, CHAKRAVARTI, ARNAB · 2014 to 2018
$6.8M
Network Lead Academic Participating Site: Memorial Sloan-Kettering Cancer CenterU10CA180791 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI AGHAJANIAN, CAROL, MORRIS, MICHAEL J · 2014 to 2018
$4.6M
NCI NIH HHS P30 CA023108NCI NIH HHS U10 CA021661NCI NIH HHS U10 CA037422NCI NIH HHS U10 CA180791NCI NIH HHS U10 CA180822NCI NIH HHS U10 CA180850NCI NIH HHS U10 CA180868NCI NIH HHS U10 CA 21661NCI NIH HHS U10 CA 37422
6 · The paper itself

Abstract

purposeThe Radiation Therapy Oncology Group 9804 study identified good-risk patients with ductal carcinoma in situ (DCIS), a breast cancer diagnosis found frequently in mammographically detected cancers, to test the benefit of radiotherapy (RT) after breast-conserving surgery compared with observation. PATIENTS AND

methodsThis prospective randomized trial (1998 to 2006) in women with mammographically detected low- or intermediate-grade DCIS, measuring less than 2.5 cm with margins ≥ 3 mm, compared RT with observation after surgery. The study was designed for 1,790 patients but was closed early because of lower than projected accrual. Six hundred thirty-six patients from the United States and Canada were entered; tamoxifen use (62%) was optional. Ipsilateral local failure (LF) was the primary end point; LF and contralateral failure were estimated using cumulative incidence, and overall and disease-free survival were estimated using the Kaplan-Meier method.

resultsMedian follow-up time was 7.17 years (range, 0.01 to 11.33 years). Two LFs occurred in the RT arm, and 19 occurred in the observation arm. At 7 years, the LF rate was 0.9% (95% CI, 0.0% to 2.2%) in the RT arm versus 6.7% (95% CI, 3.2% to 9.6%) in the observation arm (hazard ratio, 0.11; 95% CI, 0.03 to 0.47; P < .001). Grade 1 to 2 acute toxicities occurred in 30% and 76% of patients in the observation and RT arms, respectively; grade 3 or 4 toxicities occurred in 4.0% and 4.2% of patients, respectively. Late RT toxicity was grade 1 in 30%, grade 2 in 4.6%, and grade 3 in 0.7% of patients.

conclusionIn this good-risk subset of patients with DCIS, with a median follow-up of 7 years, the LF rate was low with observation but was decreased significantly with the addition of RT. Longer follow-up is planned because the timeline for LF in this setting seems protracted.

Indexed as

Mastectomy, SegmentalWatchful WaitingAdultAgedBreast NeoplasmsCanadaCarcinoma, Intraductal, NoninfiltratingDisease-Free SurvivalDisease ManagementFemaleHumansKaplan-Meier EstimateMammographyMiddle AgedNeoplasm Recurrence, LocalOdds Ratio

Identifiers

PMID25605856
PMCPMC4334775
OpenAlexW2108995265

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.