ArticleDiabetes2015
A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis.
Article in Diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
174 citing papers in PubMed, 298 citations in OpenAlex.
- Combined training increases thermogenic fat activity in patients with overweight and type 2 diabetes.International journal of obesity (2005) · 2022Trial
- Exercise intensity regulates cytokine and klotho responses in men.Nutrition & diabetes · 2021Trial
- Impact of Exercise on Cardiometabolic Component Risks in Spinal Cord-injured Humans.Medicine and science in sports and exercise · 2017Trial
- Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging.Physiological reports · 2016Trial
- A combination of aerobic and resistance training induces white adipose tissue browning.Journal of physiology and biochemistry · 2026Article
- Exercise training is associated with changes in adipocyte size and lipid metabolism in older women: cross-sectional and longitudinal study.BMC geriatrics · 2026Article
- Kiss1-FASN participates fatty acid synthesis via high-fat diet in PgVAT of female mice.Journal of lipid research · 2026Article
- Lipolysis in Health and Disease: Pathways, Regulation, and Metabolic Consequences.Current diabetes reports · 2026Review
- Multi-omic responses to acute exercise in abdominal subcutaneous adipose tissue of sedentary adults: findings from MoTrPAC.bioRxiv : the preprint server for biology · 2026Article
- The Endothelium as a Central Mediator of Exercise-Induced Metabolism and Communication.Exercise and sport sciences reviews · 2026Review
- Treadmill training or caloric restriction delays aging-associated increase in urocortin 2-induced hyperthermia in middle-aged male Wistar rats.Scientific reports · 2025Article
- Obesity and Exercise: New Insights and Perspectives.Endocrine reviews · 2025Review
- Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose Tissue.bioRxiv : the preprint server for biology · 2025Article
- Immunometabolic Interactions in Obesity: Implications for Therapeutic Strategies.Biomedicines · 2025Review
- Can Exercise-Mediated Adipose Browning Provide an Alternative Explanation for the Obesity Paradox?International journal of molecular sciences · 2025Review
- Review
- Exercise benefits yourself and your offspring: a mini-review.Frontiers in cell and developmental biology · 2025Review
- Exercise as a tool to mitigate metabolic disease.American journal of physiology. Cell physiology · 2024Review
- Non-invasive optoacoustic imaging of dermal microcirculatory revascularization in diet-induced obese mice undergoing exercise intervention.Photoacoustics · 2024Article
- Exercise training and cold exposure trigger distinct molecular adaptations to inguinal white adipose tissue.Cell reports · 2024Article
114 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Exercise training improves whole-body glucose homeostasis through effects largely attributed to adaptations in skeletal muscle; however, training also affects other tissues, including adipose tissue. To determine whether exercise-induced adaptations to adipose tissue contribute to training-induced improvements in glucose homeostasis, subcutaneous white adipose tissue (scWAT) from exercise-trained or sedentary donor mice was transplanted into the visceral cavity of sedentary recipients. Remarkably, 9 days post-transplantation, mice receiving scWAT from exercise-trained mice had improved glucose tolerance and enhanced insulin sensitivity compared with mice transplanted with scWAT from sedentary or sham-treated mice. Mice transplanted with scWAT from exercise-trained mice had increased insulin-stimulated glucose uptake in tibialis anterior and soleus muscles and brown adipose tissue, suggesting that the transplanted scWAT exerted endocrine effects. Furthermore, the deleterious effects of high-fat feeding on glucose tolerance and insulin sensitivity were completely reversed if high-fat-fed recipient mice were transplanted with scWAT from exercise-trained mice. In additional experiments, voluntary exercise training by wheel running for only 11 days resulted in profound changes in scWAT, including the increased expression of ∼1,550 genes involved in numerous cellular functions including metabolism. Exercise training causes adaptations to scWAT that elicit metabolic improvements in other tissues, demonstrating a previously unrecognized role for adipose tissue in the beneficial effects of exercise on systemic glucose homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.