ArticleNeurocritical care2015
Evidence-based guidelines for the management of large hemispheric infarction : a statement for health care professionals from the Neurocritical Care Society and the German Society for Neuro-intensive Care and Emergency Medicine.
Article in Neurocritical care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 10 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Guidelines for Neuroprognostication in Critically ill Adults with Acute Ischemic Stroke.Neurocritical care · 2026Guideline
- Neuroprotective effect of Glibenclamide in stroke: a systematic review and meta-analysis of randomized controlled trials.Acta neurologica Belgica · 2026Pooled it
- A systematic review and synthesis of global stroke guidelines on behalf of the World Stroke Organization.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- Reporting quality evaluation of the stroke clinical practice guidelines: a systematic review.Systematic reviews · 2021Pooled it
- Quality of stroke guidelines in low- and middle-income countries: a systematic review.Bulletin of the World Health Organization · 2021Pooled it
- The Role of Hypothermia in Large Hemispheric Infarction: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Pooled it
- Hemicraniectomy versus medical treatment with large MCA infarct: a review and meta-analysis.BMJ open · 2016Pooled it
- Efficacy and safety of short-term dual- versus mono-antiplatelet therapy in patients with ischemic stroke or TIA: a meta-analysis of 10 randomized controlled trials.Journal of neurology · 2016Pooled it
- [Intensive care therapy of space-occupying large hemispheric infarction. Summary of the NCS/DGNI guidelines].Der Nervenarzt · 2015Guideline
- Large diameter hemicraniectomy does not improve long-term outcome in malignant infarction.Journal of neurology · 2023Trial
- Trial
- Outcomes of Hypothermia in Addition to Decompressive Hemicraniectomy in Treatment of Malignant Middle Cerebral Artery Stroke: A Randomized Clinical Trial.JAMA neurology · 2019Trial
- Trial
- Best Available Evidence on Weaning and Extubation in Mechanically Ventilated Neurocritical Care Patients: An Evidence Summary.Nursing in critical care · 2026Review
- Malignant Cerebral Edema after Large-Core Anterior Circulation Stroke in the Thrombectomy Era: Prediction and Neurocritical Care Pathways.Neurocritical care · 2026Review
- The Effect of Cranioplasty on Cerebrospinal Fluid Dynamics in the Cerebral Aqueduct.Journal of Korean Neurosurgical Society · 2026Article
- Review
- Early versus late anticoagulation on outcomes in large hemispheric infarction: a propensity score-matched analysis.Journal of neurology · 2026Article
- Retrospective cohort study: stereotactic aspiration of necrotic tissue versus conservative medical management for malignant MCA infarction.Frontiers in surgery · 2026Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 13 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large hemispheric infarction (LHI), also known as malignant middle cerebral infarction, is a devastating disease associated with significant disability and mortality. Clinicians and family members are often faced with a paucity of high quality clinical data as they attempt to determine the most appropriate course of treatment for patients with LHI, and current stroke guidelines do not provide a detailed approach regarding the day-to-day management of these complicated patients. To address this need, the Neurocritical Care Society organized an international multidisciplinary consensus conference on the critical care management of LHI. Experts from neurocritical care, neurosurgery, neurology, interventional neuroradiology, and neuroanesthesiology from Europe and North America were recruited based on their publications and expertise. The panel devised a series of clinical questions related to LHI, and assessed the quality of data related to these questions using the Grading of Recommendation Assessment, Development and Evaluation guideline system. They then developed recommendations (denoted as strong or weak) based on the quality of the evidence, as well as the balance of benefits and harms of the studied interventions, the values and preferences of patients, and resource considerations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.