Evidence map›Paper›PMID 25605490›Full record

ArticleIranian biomedical journal2015

Association between p53 codon 72 (Arg72Pro) polymorphism and primary open-angle glaucoma in Iranian patients.

Hossein Neamatzadeh, Reza Soleimanizad, Aref Atefi, Masoud Zare-Shehneh, Saba Gharibi, Abolfazl Shekari, Amir Bahman Rahimzadeh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian biomedical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. An Updated Review on the Genetics of Primary Open Angle Glaucoma.International journal of molecular sciences · 2015
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hossein NeamatzadehHematology, Oncology and Genetic Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Reza SoleimanizadDept. of Ophthalmology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd; Iran.
Aref AtefiDept. of Microbial Biotechnology, Payam Noor University, Tehran, Iran.
Masoud Zare-ShehnehDept. of Medical Genetics, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Saba GharibiDept. of Medical Genetics, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Abolfazl ShekariDept. of Medical Genetics, Zanjan University of Medical Sciences, Zanjan, Iran.
Amir Bahman RahimzadehDept. of Hematology, Tabriz University of Medical Sciences, Tabriz, Iran.
Shahid Sadoughi University of Medical Sciences and Health Services · IRPayame Noor University · IRZanjan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlaucomatous neuropathy is a type of cell death due to apoptosis. The p53 gene is one of the regulatory genes of apoptosis. Recently, the association between the p53 gene encoding for proline at codon 72 and primary open-angle glaucoma (POAG) has been studied in some ethnic groups. This study is the first association analysis of POAG and p53 codon 72 polymorphism in Iranian patients.

methodsA cohort of 65 unrelated patients with POAG (age range from 12-62 years, mean ± SD of 40.16 ± 17.51 years) and 65 unrelated control subjects (without glaucoma, age range of 14-63 years, mean ± SD of 35.64 ± 13.61 years) were selected. In Iranian POAG patients and normal healthy controls, the p53 codon 72 polymorphism in exon 4 was amplified using polymerase chain reaction. The amplified DNA fragments were digested with the BstUI restriction enzyme, and the digestion patterns were used to identify the alleles for the polymorphic site.

resultsComparisons revealed significant differences in allele and genotype frequencies of Pro72Arg between POAG patients and control group. A higher risk of POAG was associated with allele Pro (OR = 2.1, 95% CI = 1.2-3.4) and genotype Pro/Pro (OR = 3.9, 95% CI = 0.13-12.7).

conclusionThe p53 Pro72 allele was more frequent in Iranian POAG patients than in the control group (P<0.05). The present findings show that the individuals with the Pro/Pro genotype may be more likely to develop POAG. However, additional studies are necessary to confirm this association.

Indexed as

AdolescentAdultApoptosisBase SequenceChildDNAFemaleGene FrequencyGenetic Association StudiesGenotypeGlaucomaHumansIranMaleMiddle AgedPolymorphism, Single NucleotideDNATumor Suppressor Protein p53GlaucomaIranp53Primary open-angle glaucoma

Identifiers

PMID25605490
PMCPMC4322233
OpenAlexW2145660852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.