Evidence map›Paper›PMID 25605447›Full record

ArticleJournal of exposure science & environmental epidemiology2016

Relation of dietary inorganic arsenic to serum matrix metalloproteinase-9 (MMP-9) at different threshold concentrations of tap water arsenic.

Margaret Kurzius-Spencer, Robin B Harris, Vern Hartz, Jason Roberge, Chiu-Hsieh Hsu, Mary Kay O'Rourke, Jefferey L Burgess

Open access · bronzeAbstract read
In one paragraph

Article in Journal of exposure science & environmental epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Margaret Kurzius-SpencerUniversity of Arizona, College of Medicine, Department of Pediatrics, Tucson, Arizona, USA.
Robin B HarrisUniversity of Arizona, Mel & Enid Zuckerman College of Public Health, Tucson, Arizona, USA.
Vern HartzUniversity of Arizona, Arizona Cancer Center, Tucson, Arizona, USA.
Jason RobergeCarolinas Healthcare System, Dickson Advanced Analytics Group, Charlotte, North Carolina, USA.
Chiu-Hsieh HsuUniversity of Arizona, Mel & Enid Zuckerman College of Public Health, Tucson, Arizona, USA.
Mary Kay O'RourkeUniversity of Arizona, Mel & Enid Zuckerman College of Public Health, Tucson, Arizona, USA.
Jefferey L BurgessUniversity of Arizona, Mel & Enid Zuckerman College of Public Health, Tucson, Arizona, USA.
University of Arizona · USCarolinas Healthcare System · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
SPORE in Gastrointestinal CancerP50CA095060 · NCI · UNIVERSITY OF ARIZONA · PI GERNER, EUGENE W · 2002 to 2012
$25.3M
NCI NIH HHS P30 CA023074NCI NIH HHS P50 CA095060NIEHS NIH HHS P30 ES006694
6 · The paper itself

Abstract

Arsenic (As) exposure is associated with cancer, lung and cardiovascular disease, yet the mechanisms involved are not clearly understood. Elevated matrix metalloproteinase-9 (MMP-9) levels are also associated with these diseases, as well as with exposure to water As. Our objective was to evaluate the effects of dietary components of inorganic As (iAs) intake on serum MMP-9 concentration at differing levels of tap water As. In a cross-sectional study of 214 adults, dietary iAs intake was estimated from 24-h dietary recall interviews using published iAs residue data; drinking and cooking water As intake from water samples and consumption data. Aggregate iAs intake (food plus water) was associated with elevated serum MMP-9 in mixed model regression, with and without adjustment for covariates. In models stratified by tap water As, aggregate intake was a significant positive predictor of serum MMP-9 in subjects exposed to water As≤10 μg/l. Inorganic As from food alone was associated with serum MMP-9 in subjects exposed to tap water As≤3 μg/l. Exposure to iAs from food and water combined, in areas where tap water As concentration is ≤10 μg/l, may contribute to As-induced changes in a biomarker associated with toxicity.

Indexed as

AdultAgedAged, 80 and overArizonaArsenicBiomarkersCross-Sectional StudiesDietDrinkingDrinking WaterEnvironmental ExposureFemaleHumansInterviews as TopicMaleMatrix Metalloproteinase 9ArsenicBiomarkersDrinking WaterMatrix Metalloproteinase 9Water Pollutants, Chemical

Identifiers

PMID25605447
PMCPMC4698357
OpenAlexW2084185347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.