ArticleJournal of exposure science & environmental epidemiology
Urinary polycyclic aromatic hydrocarbon metabolites as biomarkers to woodsmoke exposure - results from a controlled exposure study.
Article in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Urinary Metabolites of Polycyclic Aromatic Hydrocarbons in Firefighters: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Biomonitoring Human Exposure to Household Air Pollution and Association with Self-reported Health Symptoms - A Stove Intervention Study in Peru.Environment international · 2016Trial
- Associations of exposure to cotinine, polycyclic aromatic hydrocarbon, and metal(loid) mixtures during pregnancy with birth weight: the MIEHR study.Journal of exposure science & environmental epidemiology · 2026Article
- Epigenetic Alterations in PAH-Induced Childhood Asthma: An Intervention Using Sulforaphane.Toxics · 2025Article
- Urinary Pyrene Carboxylic Acid as a Novel Exposure Biomarker of Woodsmoke.Environmental science & technology letters · 2025Article
- Article
- Protecting Firefighters from Carcinogenic Exposure: Emerging Tools for PAH Detection and Decontamination.Biosensors · 2025Review
- Environmental and dietary factors associated with urinary OH-PAHs in mid-pregnancy in a large multi-site study.Environmental research · 2025Article
- Exposure to Polycyclic Aromatic Hydrocarbons and adverse reproductive outcomes in women: current status and future perspectives.Reviews on environmental health · 2024Review
- Health Risk Assessment of Occupational Exposures of Polycyclic Aromatic Hydrocarbons, Phthalates, and Semi-Volatile Chlorinated Organic Compounds in Urine of Commercial Fish Smokers, Ghana.Environmental health insights · 2024Article
- MicroRNAs as Potential Biomarkers of Environmental Exposure to Polycyclic Aromatic Hydrocarbons and Their Link with Inflammation and Lung Cancer.International journal of molecular sciences · 2023Review
- Human Biomonitoring of Selected Hazardous Compounds in Portugal: Part I-Lessons Learned on Polycyclic Aromatic Hydrocarbons, Metals, Metalloids, and Pesticides.Molecules (Basel, Switzerland) · 2021Review
- Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress.Environment international · 2021Article
- Urinary polycyclic aromatic hydrocarbon metabolites and mortality in the United States: A prospective analysis.PloS one · 2021Article
- Grill Workers Exposure to Polycyclic Aromatic Hydrocarbons: Levels and Excretion Profiles of the Urinary Biomarkers.International journal of environmental research and public health · 2020Article
- Cross-validation of biomonitoring methods for polycyclic aromatic hydrocarbon metabolites in human urine: Results from the formative phase of the Household Air Pollution Intervention Network (HAPIN) trial in India.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2020Article
- Evaluation of Interventions to Reduce Firefighter Exposures.Journal of occupational and environmental medicine · 2020Article
- Article
- Health effects of exposure to diesel exhaust in diesel-powered trains.Particle and fibre toxicology · 2019Article
- Urinary biomarkers of polycyclic aromatic hydrocarbons in pre- and peri-pubertal girls in Northern California: Predictors of exposure and temporal variability.Environmental research · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Woodsmoke contains harmful components - such as fine particulate matter (PM2.5) and polycyclic aromatic hydrocarbons (PAHs) - and impacts more than half of the global population. We investigated urinary hydroxylated PAH metabolites (OH-PAHs) as woodsmoke exposure biomarkers in nine non-smoking volunteers experimentally exposed to a wood fire. Individual urine samples were collected from 24-h before to 48-h after the exposure and personal PM2.5 samples were collected during the 2-h woodsmoke exposure. Concentrations of nine OH-PAHs increased by 1.8-7.2 times within 2.3-19.3 h, and returned to baseline approximately 24 h after the exposure. 2-Naphthol (2-NAP) had the largest post-exposure increase and exhibited a clear excretion pattern in all participants. The level of urinary OH-PAHs, except 1-hydroxypyrene (1-PYR), correlated with those of PM2.5, levoglucosan and PAHs in personal PM2.5 samples. This finding suggests that several urinary OH-PAHs, especially 2-NAP, are potential exposure biomarkers to woodsmoke; by contrast, 1-PYR may not be a suitable biomarker. Compared with levoglucosan and methoxyphenols - two other urinary woodsmoke biomarkers that were measured in the same study and reported previously - OH-PAHs might be better biomarkers based on sensitivity, robustness and stability, particularly under suboptimal sampling and storage conditions, like in epidemiological studies carried out in less developed areas.
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Registered trials
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