Evidence map›Paper›PMID 25605361›Full record

ArticleAntimicrobial agents and chemotherapy2015

In vivo effect of flucloxacillin in experimental endocarditis caused by mecC-positive staphylococcus aureus showing temperature-dependent susceptibility in vitro.

Stefano Mancini, Frédéric Laurent, Tiago R Veloso, Marlyse Giddey, Jacques Vouillamoz, François Vandenesch, Philippe Moreillon, José M Entenza

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Methicillin-resistant Staphylococcus aureus with mecC: a description of 45 human cases in southern Sweden.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Stefano ManciniDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Frédéric LaurentNational Reference Centre for Staphylococci, Hospices Civils de Lyon, International Center of Infectious Research, INSERM U1111, University of Lyon, Lyon, France.
Tiago R VelosoDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Marlyse GiddeyDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Jacques VouillamozDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
François VandeneschNational Reference Centre for Staphylococci, Hospices Civils de Lyon, International Center of Infectious Research, INSERM U1111, University of Lyon, Lyon, France.
Philippe MoreillonDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
José M EntenzaDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland jose.entenza@unil.ch.
University of Lausanne · CHUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) carrying the mecC gene (mecC-MRSA) exhibited at 37°C MICs of oxacillin close to those of methicillin-susceptible S. aureus (MSSA). We investigated whether at this temperature, mecC-MRSA strains respond to flucloxacillin treatment like MSSA strains, using a rat model of endocarditis. Flucloxacillin (human-like kinetics of 2 g intravenously every 6 h) cured 80 to 100% of aortic vegetations infected with five different mecC-MRSA strains. These results suggest that mecC-MRSA infections may successfully respond to treatment with β-lactams.

Indexed as

AnimalsAnti-Bacterial AgentsAortaCefoxitinChromatography, Micellar Electrokinetic CapillaryEndocarditis, BacterialFloxacillinInfusion PumpsMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsOxacillinRatsStaphylococcal InfectionsTemperatureAnti-Bacterial AgentsCefoxitinFloxacillinOxacillin

Identifiers

PMID25605361
PMCPMC4356768
OpenAlexW1965818661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.