ArticlePlant cell reports2015
Development of high oleic oil crop platform in flax through RNAi-mediated multiple FAD2 gene silencing.
Article in Plant cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- Effect of High Temperature and Drought on the Fatty Acid Composition of Oil of Different Linseed Varieties and Its Association with Gene Expression.International journal of molecular sciences · 2026Article
- Genetic transformation and genome editing of flax (Frontiers in plant science · 2026Review
- Lipid regulation inFrontiers in plant science · 2026Review
- The Construction of a Mutant Library of Linseed and the Molecular Mechanism of High Oleic Acid Mutants from a Multi-Omics Perspective.Plants (Basel, Switzerland) · 2025Article
- Expression ofPlants (Basel, Switzerland) · 2024Article
- Comparison of nutritional quality of fourteen wildHeliyon · 2023Article
- KeyInternational journal of molecular sciences · 2023Article
- Integrated lipidomic and transcriptomic analyses reveal the mechanism of lipid biosynthesis and accumulation during seed development in sesame.Frontiers in plant science · 2023Article
- Enhancing the accumulation of linoleic acid and α-linolenic acid through the pre-harvest ethylene treatment inFrontiers in plant science · 2023Article
- Development and Complex Application of Methods for the Identification of Mutations in thePlants (Basel, Switzerland) · 2022Article
- Development of a High Oleic Cardoon Cell Culture Platform byFrontiers in plant science · 2022Article
- Molecular Approaches Reduce Saturates and EliminateFrontiers in plant science · 2022Review
- Crop Quality Improvement Through Genome Editing Strategy.Frontiers in genome editing · 2021Review
- Increasing Monounsaturated Fatty Acid Contents in HexaploidFrontiers in plant science · 2021Article
- Characterization and validation of olive FAD and SAD gene families: expression analysis in different tissues and during fruit development.Molecular biology reports · 2020Article
- Seed-specific RNAi in safflower generates a superhigh oleic oil with extended oxidative stability.Plant biotechnology journal · 2018Article
- Improved oil quality in transgenic soybean seeds by RNAi-mediated knockdown of GmFAD2-1B.Transgenic research · 2018Article
- TheFrontiers in plant science · 2017Review
- Significant increase of oleic acid level in the wild species Lepidium campestre through direct gene silencing.Plant cell reports · 2016Article
- Structural organization of fatty acid desaturase loci in linseed lines with contrasting linolenic acid contents.Functional & integrative genomics · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageSimultaneous gene silencing of both FAD2 genes in high linoleic acid flax leads to high level of oleic acid, which is stable across multiple generations. High oleic oil is one of the preferred traits in oil crop engineering due to its stability and multiple applications as an industrial feedstock. Flax possesses two isoforms of FAD2 enzymes that desaturate monounsaturated oleic acid to polyunsaturated linoleic acid. These two enzymes are encoded by two FAD2 genes. By simultaneous gene silencing both FAD2 genes in high linoleic acid flax, Linola, high level of oleic acid up to 80% was achieved in 69 silencing lines. The high oleic trait was stable across multiple generations with oleic acid reaching up to 77% in homozygote T3 progeny. The RNAi-mediated gene-silencing approach generated high oleic linseed oil, as well as a high oleic platform that can be exploited for further fatty acid engineering.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.