Evidence map›Paper›PMID 25604807›Full record

ArticleBJU international2016

Causes of death in men with localized prostate cancer: a nationwide, population-based study.

Mieke Van Hemelrijck, Yasin Folkvaljon, Jan Adolfsson, Olof Akre, Lars Holmberg, Hans Garmo, Pär Stattin

Abstract read
In one paragraph

Article in BJU international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mieke Van HemelrijckDivision of Cancer Studies, Cancer Epidemiology Group, School of Medicine, King's College London, London, UK.
Yasin FolkvaljonRegional Cancer Centre, Uppsala Örebro, Uppsala, Sweden.
Jan AdolfssonCLINTEC Department, Karolinska Institutet, Stockholm, Sweden.
Olof AkreClinical Epidemiology Unit, Department of Medicine (Solna), Karolinska Institute, Stockholm, Sweden.
Lars HolmbergDivision of Cancer Studies, Cancer Epidemiology Group, School of Medicine, King's College London, London, UK.
Hans GarmoDivision of Cancer Studies, Cancer Epidemiology Group, School of Medicine, King's College London, London, UK.
Pär StattinClinical Epidemiology Unit, Department of Medicine (Solna), Karolinska Institute, Stockholm, Sweden.

Funding

Cancer Research UK
6 · The paper itself

Abstract

objectiveTo detail the distribution of causes of death from localized prostate cancer (PCa). PATIENTS AND

methodsThe database PCBase Sweden links the Swedish National Prostate Cancer Register with other nationwide population-based healthcare registers. We selected all 57 187 men diagnosed with localized PCa between 1997 and 2009 and their 114 374 PCa-free control subjects, matched according to age and county of residence. Mortality was calculated using competing risk regression analyses, taking into account PCa risk category, age and Charlson comorbidity index (CCI).

resultsIn men with low-risk PCa, all-cause mortality was lower compared with that in corresponding PCa-free men: 10-year all-cause mortality was 18% for men diagnosed at age 70 years, with a CCI score of 0, and 21% among corresponding control subjects. Of these cases, 31% died from cardiovascular disease (CVD) compared with 37% of the corresponding control subjects. For men with low-risk PCa, 10-year PCa-mortality was 0.4, 1 and 3% when diagnosed at age 50, 60 and 70 years, respectively. PCa was the third most common cause of death (18%), after CVD (31%) and other cancers (30%). By contrast, PCa was the most common cause of death in men with intermediate- and high-risk localized PCa.

conclusionsMen with low-risk PCa had lower all-cause mortality than PCa-free men because of lower CVD mortality, driven by early detection selection; however, for men with intermediate- or high-risk disease, the rate of PCa death was substantial, irrespective of CCI score, and this was even more pronounced for those diagnosed at age 50 or 60 years.

Indexed as

AdultAgedAged, 80 and overCase-Control StudiesCause of DeathHumansMaleMiddle AgedProstatic NeoplasmsRisk FactorsSwedencomorbiditiescurative treatmentlocalized diseaseprostate cancer death

Identifiers

PMID25604807
PMCPMC4832314

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.