ArticleEuropean journal of clinical nutrition2015
Compliance with preoperative oral nutritional supplements in patients at nutritional risk--only a question of will?
Article in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00512213 (Immunonutrition Versus Standard Enteral Nutrition Before Major Surgery), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Immunonutrition Versus Standard Enteral Nutrition Before Major Surgery: A Single-center Double-blinded Controlled Randomized Superiority Trial
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Effects of enteral nutritional rich in n-3 polyunsaturated fatty acids on the nutritional status of gastrointestinal cancer patients: a systematic review and meta-analysis.European journal of clinical nutrition · 2020Pooled it
- Improving Compliance and Satisfaction With Quality Coffee Intake to Enhance Bowel Recovery After Colorectal Surgery: A Feasibility Study.Health science reports · 2026Article
- Adherence to Oral Nutritional Supplements: A Review of Trends in Intervention Characteristics and Terminology Use Since the Year 2000.Food science & nutrition · 2025Review
- Definition and assessment of adherence to oral nutritional supplements in patients with neoplasms: a scoping review.BMC cancer · 2024Article
- Bovine Colostrum Treatment of Specific Cancer Types: Current Evidence and Future Opportunities.Molecules (Basel, Switzerland) · 2022Review
- Preferences for oral nutritional supplement therapy among postoperative patients with gastric cancer: a discrete choice experiment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Review
- Study protocol for feasibility and safety of adopting early oral feeding in post total laparoscopic total gastrectomy (overlap esophagojejunostomy): A multicentre randomized controlled trial.Frontiers in nutrition · 2022Article
- Screening, assessment and management of perioperative malnutrition: a survey of UK practice.Perioperative medicine (London, England) · 2021Article
- Oral Nutritional Supplements and Enteral Nutrition in Patients with Gastrointestinal Surgery.Nutrients · 2021Review
- [Perioperative nutritional supplementation-what is really evidence based?]Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Review
- Article
- Low awareness of community-dwelling older adults on the importance of dietary protein: new insights from four qualitative studies.Journal of nutritional science · 2021Article
- High Adherence to Oral Nutrition Supplements Prescribed by Dietitians: A Cross-Sectional Study on Hospital Outpatients.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2019Article
- Article
- Article
- Serum Pre-Albumin Predicts the Clinical Outcome in Metastatic Castration-Resistant Prostate Cancer Patients Treated With Abiraterone.Journal of Cancer · 2017Article
- Optimizing the electronic health record to standardize administration and documentation of nutritional supplements.BMJ quality improvement reports · 2017Article
- Perioperative nutritional assessment and management of patients undergoing gastrointestinal surgery.Annals of gastroenterologyReview
- Opportunities for Patient Participation in Perioperative Malnutrition Care: A Qualitative Study.SAGE open nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesPreoperative nutrition has been shown to reduce morbidity after major gastrointestinal (GI) surgery in selected patients at risk. In a randomized trial performed recently (NCT00512213), almost half of the patients, however, did not consume the recommended dose of nutritional intervention. The present study aimed to identify the risk factors for noncompliance. SUBJECTS/
methodsDemographic (n = 5) and nutritional (n = 21) parameters for this retrospective analysis were obtained from a prospectively maintained database. The outcome of interest was compliance with the allocated intervention (ingestion of ⩾ 11/15 preoperative oral nutritional supplement units). Uni- and multivariate analyses of potential risk factors for noncompliance were performed.
resultsThe final analysis included 141 patients with complete data sets for the purpose of the study. Fifty-nine patients (42%) were considered noncompliant. Univariate analysis identified low C-reactive protein levels (P = 0.015), decreased recent food intake (P = 0.032) and, as a trend, low hemoglobin (P = 0.065) and low pre-albumin (P = 0.056) levels as risk factors for decreased compliance. However, none of them was retained as an independent risk factor after multivariate analysis. Interestingly, 17 potential explanatory parameters, such as upper GI cancer, weight loss, reduced appetite or co-morbidities, did not show any significant correlation with reduced intake of nutritional supplements.
conclusionsReduced compliance with preoperative nutritional interventions remains a major issue because the expected benefit depends on the actual intake. Seemingly, obvious reasons could not be retained as valid explanations. Compliance seems thus to be primarily a question of will and information; the importance of nutritional supplementation needs to be emphasized by specific patients' education.
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