ArticlePlant physiology2015
GROWTH REGULATING FACTOR5 stimulates Arabidopsis chloroplast division, photosynthesis, and leaf longevity.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 186 citations in OpenAlex.
- Interplay among ZF-HD and GRF transcription factors during Arabidopsis leaf development.Plant physiology · 2023Pooled it
- Plant organelle division orchestrated by the mosaic machinery of endosymbiotic relics and eukaryotic host factors.Plant physiology · 2026Review
- Genome-Wide Analysis of the GRF-GIF Module inInternational journal of molecular sciences · 2026Article
- Traversing the effects of ploidy changes in different Eragrostis curvula genotypes through high-throughput RNA sequencing.The plant genome · 2026Article
- The miR396f-GRF7 Module Confers Thermotolerance in Rice.Rice (New York, N.Y.) · 2026Article
- The GATA8-GRF5-XTH9 feed-forward loop regulates cell size in poplar.Horticulture research · 2026Article
- Genome-wide association study (GWAS) and transcriptome analysis reveal new candidate genes for leaf size in alfalfa.BMC plant biology · 2026Article
- Effect of phosphorus deficiency on biomass and root system architecture in diverseFrontiers in plant science · 2026Article
- Pod photosynthesis: a new frontier for developing stress-resilient and high-yielding crops.Plant & cell physiology · 2025Review
- Genome-Wide Identification and Characterization of Growth Regulatory Factor Gene Family inPlants (Basel, Switzerland) · 2025Article
- Identification of key candidate genes regulating hundred-grain weight in the maize inbred line Ye107 from Southern China.Plant cell reports · 2025Article
- OsLC1, a transaldolase, regulates cell patterning and leaf morphology through modulation of secondary metabolism.Plant biotechnology journal · 2025Article
- Identification of the citrus GRF gene family and its expression in fruit peel thickening mediated by gibberellin.BMC plant biology · 2025Article
- Dressed Up to the Nines: The Interplay of Phytohormones Signaling and Redox Metabolism During Plant Response to Drought.Plants (Basel, Switzerland) · 2025Review
- Functional Mechanisms and the Application of Developmental Regulators for Improving Genetic Transformation in Plants.Plants (Basel, Switzerland) · 2024Review
- Genome-wide molecular evolution analysis of the GRF and GIF gene families in Plantae (Archaeplastida).BMC genomics · 2024Article
- Genome-wide identification of the GRF family in sweet orange (Citrus sinensis) and functional analysis of the CsGRF04 in response to multiple abiotic stresses.BMC genomics · 2024Article
- CRF transcription factors in the trade-off between abiotic stress response and plant developmental processes.Frontiers in genetics · 2024Review
- Growth-regulating factor 15-mediated vascular cambium differentiation positively regulates wood formation in hybrid poplar (Frontiers in plant science · 2024Article
- Genome-wide characterization of the GRF transcription factors in potato (Frontiers in plant science · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arabidopsis (Arabidopsis thaliana) leaf development relies on subsequent phases of cell proliferation and cell expansion. During the proliferation phase, chloroplasts need to divide extensively, and during the transition from cell proliferation to expansion, they differentiate into photosynthetically active chloroplasts, providing the plant with energy. The transcription factor GROWTH REGULATING FACTOR5 (GRF5) promotes the duration of the cell proliferation period during leaf development. Here, it is shown that GRF5 also stimulates chloroplast division, resulting in a higher chloroplast number per cell with a concomitant increase in chlorophyll levels in 35S:GRF5 leaves, which can sustain higher rates of photosynthesis. Moreover, 35S:GRF5 plants show delayed leaf senescence and are more tolerant for growth on nitrogen-depleted medium. Cytokinins also stimulate leaf growth in part by extending the cell proliferation phase, simultaneously delaying the onset of the cell expansion phase. In addition, cytokinins are known to be involved in chloroplast development, nitrogen signaling, and senescence. Evidence is provided that GRF5 and cytokinins synergistically enhance cell division and chlorophyll retention after dark-induced senescence, which suggests that they also cooperate to stimulate chloroplast division and nitrogen assimilation. Taken together with the increased leaf size, ectopic expression of GRF5 has great potential to improve plant productivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.