ArticleJournal of neurovirology2015
Clinical associations of white matter damage in cART-treated HIV-positive children in South Africa.
Article in Journal of neurovirology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Associations between Neuroimaging Measures and Cognitive Performance in Children, Adolescents, and Youth Living With HIV-a Systematic Review.Current HIV/AIDS reports · 2025Pooled it
- HIV-Associated Cognitive Impairment in Perinatally Infected Children: A Meta-analysis.Pediatrics · 2016Pooled it
- Persistent impact of antenatal maternal anaemia on child brain structure at 6-7 years of age: a South African child health study.BMC medicine · 2025Article
- Understanding the impact of congenital infections and perinatal viral exposures on the developing brain using white matter magnetic resonance imaging: a scoping review.BMC medical imaging · 2024Article
- Persistent Impact of Antenatal Maternal Anaemia on Child Brain Structure at 6-7 Years of Age: A South African Child Health Study.Research square · 2024Article
- Persistent accelerated epigenetic ageing in a longitudinal cohort of vertically infected HIV-positive adolescents.Journal of neurovirology · 2023Article
- Multimodal magnetic resonance neuroimaging measures characteristic of early cART-treated pediatric HIV: A feature selection approach.Human brain mapping · 2022Article
- Altered White Matter Tracts in the Somatosensory, Salience, Motor, and Default Mode Networks in 7-Year-Old Children Living with Human Immunodeficiency Virus: A Tractographic Analysis.Brain connectivity · 2022Article
- Evaluation of a low-resource screening strategy for ophthalmic pathologies and associated neurological morbidity in an older Tanzanian HIV-positive population.Scientific reports · 2022Article
- Alcohol use is associated with mental health problems and brain structural alterations in adolescents with perinatally acquired HIV infection on ART.Alcohol (Fayetteville, N.Y.) · 2021Article
- Reduced neuronal population in the dorsolateral prefrontal cortex in infant macaques infected with simian immunodeficiency virus (SIV).Journal of neurovirology · 2021Article
- White matter of perinatally HIV infected older youths shows low frequency fluctuations that may reflect glial cycling.Scientific reports · 2021Article
- Neurocognitive Complications of Pediatric HIV Infections.Current topics in behavioral neurosciences · 2021Article
- Fixel-Based Analysis and Free Water Corrected DTI Evaluation of HIV-Associated Neurocognitive Disorders.Frontiers in neurology · 2021Article
- State of the Mind: Growing up with HIV.Paediatric drugs · 2020Review
- Diffusion tensor magnetic resonance imaging of white matter integrity in patients with HIV-associated neurocognitive disorders.Annals of translational medicine · 2020Article
- Machine-learning classification of neurocognitive performance in children with perinatal HIV initiating de novo antiretroviral therapy.AIDS (London, England) · 2020Article
- Brain structure of perinatally HIV-infected patients on long-term treatment: A systematic review.Neurology. Clinical practice · 2019Review
- White matter microstructure among perinatally HIV-infected youth: a diffusion tensor imaging study.Journal of neurovirology · 2019Article
- Systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric HIV.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A range of factors contributes to white matter damage in vertically infected HIV-positive children. These may include combination antiretroviral treatment (cART) regimen, sociodemographic factors, nutritional-hematological status, HIV-relevant clinical variables, and cognitive functioning. We explored associations between a number of these factors and diffusion tensor imaging (DTI) measures in 50 cART-treated children aged 6 to 15 years. Fractional anisotropy (FA), mean diffusion (MD), radial diffusion (RD), and axial diffusion (AD) were derived from 48 cerebral white matter regions. Significant associations between a number of the clinical variables and white matter integrity were found. Decreased FA, a measure of neuronal damage, was associated with being on second-line cART, low hemoglobin, and younger age. Children with increased MD, a measure of neuronal damage, were younger, had reduced albumin and hemoglobin, and increased viral load. Decreased AD, a measure of axonal damage, was associated with increased viral load and total protein, decreased albumin and hemoglobin, younger age, poorer fronto-striatal cognition, and being on second-line cART. Increased RD, a measure of myelin loss, was associated with younger age, low current CD4 count, low albumin and hemoglobin, and higher viral load and total protein. The current findings underline the possible association of first-line treatment failure with white matter brain dysfunction in pediatric neuroHIV and the importance of examining the effects of HIV disease in the context of treatable clinical variables such as anemia and nutritional status.
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Registered trials
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