Evidence map›Paper›PMID 25604327›Full record

ArticleProteomics2015

Workflows for automated downstream data analysis and visualization in large-scale computational mass spectrometry.

Stephan Aiche, Timo Sachsenberg, Erhan Kenar, Mathias Walzer, Bernd Wiswedel, Theresa Kristl, Matthew Boyles, Albert Duschl, Christian G Huber, Michael R Berthold and 2 more

Abstract read
In one paragraph

Article in Proteomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Comprehensive Peptide Mapping Is Crucial for Proteogenomics and Proteomics.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stephan AicheDepartment of Mathematics and Computer Science, Freie Universität Berlin, Berlin, Germany.
Timo Sachsenberg
Erhan Kenar
Mathias Walzer
Bernd Wiswedel
Theresa Kristl
Matthew Boyles
Albert Duschl
Christian G Huber
Michael R Berthold
Knut Reinert
Oliver Kohlbacher

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MS-based proteomics and metabolomics are rapidly evolving research fields driven by the development of novel instruments, experimental approaches, and analysis methods. Monolithic analysis tools perform well on single tasks but lack the flexibility to cope with the constantly changing requirements and experimental setups. Workflow systems, which combine small processing tools into complex analysis pipelines, allow custom-tailored and flexible data-processing workflows that can be published or shared with collaborators. In this article, we present the integration of established tools for computational MS from the open-source software framework OpenMS into the workflow engine Konstanz Information Miner (KNIME) for the analysis of large datasets and production of high-quality visualizations. We provide example workflows to demonstrate combined data processing and visualization for three diverse tasks in computational MS: isobaric mass tag based quantitation in complex experimental setups, label-free quantitation and identification of metabolites, and quality control for proteomics experiments.

Indexed as

SoftwareComputer GraphicsData Interpretation, StatisticalHumansMetabolomicsProteomicsTandem Mass SpectrometryWorkflowKNIMEMetabolomicsOpenMSProteomicsWorkflows

Identifiers

PMID25604327
PMCPMC4415483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.