ArticleThe Journal of physiology2015
Dynamic cortical lateralization during olfactory discrimination learning.
Article in The Journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lavender aromatherapy: A systematic review from essential oil quality and administration methods to cognitive enhancing effects.Applied psychology. Health and well-being · 2022Pooled it
- Article
- Distinct goal location beta frequency dynamics in hippocampus and prefrontal cortex across learning.bioRxiv : the preprint server for biology · 2026Article
- Dynamic changes in hemispheric lateralization in major depressive disorder correlate with neurotransmitter and genetic profiles: a DIRECT consortium study.Translational psychiatry · 2025Article
- Anterior piriform cortex dysfunction underlies autism spectrum disorders-related olfactory deficits in Fmr1 conditional deletion mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- A Global Survey on the Perception of Conservationists Regarding Animal Consciousness.Animals : an open access journal from MDPI · 2025Article
- The unity and diversity of verbal and visuospatial creativity: Dynamic changes in hemispheric lateralisation.Human brain mapping · 2023Article
- Loss of TRPC2 function in mice alters sex differences in brain regions regulating social behaviors.The Journal of comparative neurology · 2023Article
- High-Frequency Local Field Potential Oscillations May Modulate Aggressive Behaviors in Mice.Biology · 2022Article
- Lessons from behavioral lateralization in olfaction.Brain structure & function · 2022Review
- Dynamic changes in brain lateralization correlate with human cognitive performance.PLoS biology · 2022Article
- Smell-induced gamma oscillations in human olfactory cortex are required for accurate perception of odor identity.PLoS biology · 2022Article
- Validation of Olfactory Network Based on Brain Structural Connectivity and Its Association With Olfactory Test Scores.Frontiers in systems neuroscience · 2021Article
- Assessment of direct knowledge of the human olfactory system.Experimental neurology · 2020Review
- Bilateral and unilateral odor processing and odor perception.Communications biology · 2020Review
- High beta rhythm amplitude in olfactory learning signs a well-consolidated and non-flexible behavioral state.Scientific reports · 2019Article
- Multisensory learning between odor and sound enhances beta oscillations.Scientific reports · 2019Article
- Article
- Rearrangement of the Prefrontal Cortex Neural Activity in Both Hemispheres during Learning.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2018Article
- Weighted Random Support Vector Machine Clusters Analysis of Resting-State fMRI in Mild Cognitive Impairment.Frontiers in psychiatry · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Bilateral cortical circuits are not necessarily symmetrical. Asymmetry, or cerebral lateralization, allows functional specialization of bilateral brain regions and has been described in humans for such diverse functions as perception, memory and emotion. There is also evidence for asymmetry in the human olfactory system, although evidence in non-human animal models is lacking. In the present study, we took advantage of the known changes in olfactory cortical local field potentials that occur over the course of odour discrimination training to test for functional asymmetry in piriform cortical activity during learning. Both right and left piriform cortex local field potential activities were recorded. The results obtained demonstrate a robust interhemispheric asymmetry in anterior piriform cortex activity that emerges during specific stages of odour discrimination learning, with a transient bias toward the left hemisphere. This asymmetry is not apparent during error trials. Furthermore, functional connectivity (coherence) between the bilateral anterior piriform cortices is learning- and context-dependent. Steady-state interhemispheric anterior piriform cortex coherence is reduced during the initial stages of learning and then recovers as animals acquire competent performance. The decrease in coherence is seen relative to bilateral coherence expressed in the home cage, which remains stable across conditioning days. Similarly, transient, trial-related interhemispheric coherence increases with task competence. Taken together, the results demonstrate transient asymmetry in piriform cortical function during odour discrimination learning until mastery, suggesting that each piriform cortex may contribute something unique to odour memory.
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