Evidence map›Paper›PMID 25603781›Full record

ArticleLipids2015

2,2'-Bis(monoacylglycero) PO4 (BMP), but Not 3,1'-BMP, increases membrane curvature stress to enhance α-tocopherol transfer protein binding to membranes.

Matilda Baptist, Candace Panagabko, Jonathan D Nickels, John Katsaras, Jeffrey Atkinson

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Lipids, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Matilda BaptistChemistry and Centre for Biotechnology, Brock University, St. Catharines, Canada.
Candace Panagabko
Jonathan D Nickels
John Katsaras
Jeffrey Atkinson
Brock University · CAOak Ridge National Laboratory · US

Funding

Functions of Tocopherol Transfer TroteinR01DK067494 · NIDDK · CORNELL UNIVERSITY ITHACA · PI MANOR, DANNY · 2004 to 2012
$2.8M
NIDDK NIH HHS DK067494
6 · The paper itself

Abstract

Previous work revealed that α-tocopherol transfer protein (α-TTP) co-localizes with bis(monoacylglycero)phosphate (BMP) in late endosomes. BMP is a lipid unique to late endosomes and is believed to induce membrane curvature and support the multivesicular nature of this organelle. We examined the effect of BMP on α-TTP binding to membranes using dual polarization interferometry and vesicle-binding assay. α-TTP binding to membranes is increased by the curvature-inducing lipid BMP. α-TTP binds to membranes with greater affinity when they contain the 2,2'-BMP versus 3,1'-BMP isomers.

Indexed as

AnimalsCarrier ProteinsCell MembraneEndosomesHumansInterferometryLiverPhosphatesStress, Physiologicalalpha-tocopherol transfer proteinCarrier ProteinsPhosphates

Identifiers

PMID25603781
OpenAlexW1988681502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.