ArticleBiomedical engineering online2015
Artery buckling affects the mechanical stress in atherosclerotic plaques.
Article in Biomedical engineering online, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Growth directions and stiffness across cell layers determine whether tissues stay smooth or buckle.Current biology : CB · 2026Article
- A computational framework to optimize the mechanical behavior of synthetic vascular grafts.Journal of the mechanical behavior of biomedical materials · 2025Article
- Enhanced Efficiency of Sequential Cutting Balloon Angioplasty in Calcified Coronary Artery Disease: The RODIN-CUT Technique.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Article
- Simple model of atherosclerosis in cylindrical arteries: impact of anisotropic growth on Glagov remodeling.Mathematical medicine and biology : a journal of the IMA · 2021Article
- Buckling of Arteries With Noncircular Cross Sections: Theory and Finite Element Simulations.Frontiers in physiology · 2021Article
- [Effect of pushing manipulation on Qiaogong acupoint on hemodynamics in cynomolgus monkeys with mild carotid atherosclerotic plaques].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Article
- Cardiovascular diseases and vulnerable plaques: data, modeling, predictions and clinical applications.Biomedical engineering online · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundTortuous arteries are often seen in patients with hypertension and atherosclerosis. While the mechanical stress in atherosclerotic plaque under lumen pressure has been studied extensively, the mechanical stability of atherosclerotic arteries and subsequent effect on the plaque stress remain unknown. To this end, we investigated the buckling and post-buckling behavior of model stenotic coronary arteries with symmetric and asymmetric plaque.
methodsBuckling analysis for a model coronary artery with symmetric and asymmetric plaque was conducted using finite element analysis based on the dimensions and nonlinear anisotropic materials properties reported in the literature.
resultsArtery with asymmetric plaque had lower critical buckling pressure compared to the artery with symmetric plaque and control artery. Buckling increased the peak stress in the plaque and led to the development of a high stress concentration in artery with asymmetric plaque. Stiffer calcified tissue and severe stenosis increased the critical buckling pressure of the artery with asymmetric plaque.
conclusionsArteries with atherosclerotic plaques are prone to mechanical buckling which leads to a high stress concentration in the plaques that can possibly make the plaques prone to rupture.
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