Trial reportBone2015
Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study.
Trial report in Bone, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01330914 (Effects of Gastric Bypass Surgery on Calcium Metabolism and the Skeleton), which is not on this map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Gastric Bypass Surgery on Calcium Metabolism and the Skeleton
Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Changes in Bone Marrow Fat upon Dietary-Induced Weight Loss.Nutrients · 2020Trial
- Influence of sleeve gastrectomy on bone marrow fat in metabolic syndrome patients with and without diabetes: a prospective follow-up study.Hormones (Athens, Greece) · 2025Article
- Function and Regulation of Bone Marrow Adipose Tissue in Health and Disease: State of the Field and Clinical Considerations.Comprehensive Physiology · 2024Review
- Bone marrow adipose tissue composition and glycemic improvements after gastric bypass surgery.Bone reports · 2022Article
- Article
- The dynamics of human bone marrow adipose tissue in response to feeding and fasting.JCI insight · 2021Article
- Zoledronic acid for prevention of bone loss in patients receiving bariatric surgery.Bone reports · 2021Article
- Long-term Bone Loss and Deterioration of Microarchitecture After Gastric Bypass in African American and Latina Women.The Journal of clinical endocrinology and metabolism · 2021Article
- Effects of Sleeve Gastrectomy on Bone Marrow Adipose Tissue in Adolescents and Young Adults with Obesity.The Journal of clinical endocrinology and metabolism · 2020Article
- Fat and bone: the multiperspective analysis of a close relationship.Quantitative imaging in medicine and surgery · 2020Review
- Vertebral Bone Marrow Fat Is independently Associated to VAT but Not to SAT: KORA FF4-Whole-Body MR Imaging in a Population-Based Cohort.Nutrients · 2020Article
- G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche.The Journal of clinical investigation · 2019Article
- Influence of obesity on surgical complications of patients with ovarian tumors.Oncology letters · 2019Article
- Changes in marrow adipose tissue with short-term changes in weight in premenopausal women with anorexia nervosa.European journal of endocrinology · 2019Article
- Thin bones: Vitamin D and calcium handling after bariatric surgery.Bone reports · 2018Article
- Quantitative MRI and spectroscopy of bone marrow.Journal of magnetic resonance imaging : JMRI · 2018Review
- Clinical implications of bone marrow adiposity.Journal of internal medicine · 2018Review
- Bone Marrow Fat Changes After Gastric Bypass Surgery Are Associated With Loss of Bone Mass.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Bone marrow fat may serve a metabolic role distinct from other fat depots, and it may be altered by metabolic conditions including diabetes. Caloric restriction paradoxically increases marrow fat in mice, and women with anorexia nervosa have high marrow fat. The longitudinal effect of weight loss on marrow fat in humans is unknown. We hypothesized that marrow fat increases after Roux-en-Y gastric bypass (RYGB) surgery, as total body fat decreases. In a pilot study of 11 morbidly obese women (6 diabetic, 5 nondiabetic), we measured vertebral marrow fat content (percentage fat fraction) before and 6 months after RYGB using magnetic resonance spectroscopy. Total body fat mass declined in all participants (mean ± SD decline 19.1 ± 6.1 kg or 36.5% ± 10.9%, p<0.001). Areal bone mineral density (BMD) decreased by 5.2% ± 3.5% and 4.1% ± 2.6% at the femoral neck and total hip, respectively, and volumetric BMD decreased at the spine by 7.4% ± 2.8% (p<0.001 for all). Effects of RYGB on marrow fat differed by diabetes status (adjusted p=0.04). There was little mean change in marrow fat in nondiabetic women (mean +0.9%, 95% CI -10.0 to +11.7%, p=0.84). In contrast, marrow fat decreased in diabetic women (-7.5%, 95% CI -15.2 to +0.1%, p=0.05). Changes in total body fat mass and marrow fat were inversely correlated among nondiabetic (r=-0.96, p=0.01) but not diabetic (r=0.52, p=0.29) participants. In conclusion, among those without diabetes, marrow fat is maintained on average after RYGB, despite dramatic declines in overall fat mass. Among those with diabetes, RYGB may reduce marrow fat. Thus, future studies of marrow fat should take diabetes status into account. Marrow fat may have unique metabolic behavior compared with other fat depots.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.