Evidence map›Paper›PMID 25603414›Full record

ArticleTranslational psychiatry2015

Analyzing the influence of BDNF heterozygosity on spatial memory response to 17β-estradiol.

Y W C Wu, X Du, M van den Buuse, R A Hill

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  8. Sex Differences in Psychosis: Focus on Animal Models.Current topics in behavioral neurosciences · 2023
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  15. Brain-derived neurotrophic factor ValMolecular psychiatry · 2018
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  18. Bisphenol A Impairs Synaptic Plasticity by Both Pre- and Postsynaptic Mechanisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Y W C Wu1] Behavioural Neuroscience Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia [2] Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC, Australia.
X DuBehavioural Neuroscience Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
M van den Buuse1] Behavioural Neuroscience Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia [2] Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC, Australia [3] School of Psychological Science, La Trobe University, Melbourne, VIC, Australia.
R A HillBehavioural Neuroscience Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
Florey Institute of Neuroscience and Mental Health · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent use of estrogen-based therapies as adjunctive treatments for the cognitive impairments of schizophrenia has produced promising results; however the mechanism behind estrogen-based cognitive enhancement is relatively unknown. Brain-derived neurotrophic factor (BDNF) regulates learning and memory and its expression is highly responsive to estradiol. We recently found that estradiol modulates the expression of hippocampal parvalbumin-positive GABAergic interneurons, known to regulate neuronal synchrony and cognitive function. What is unknown is whether disruptions to the aforementioned estradiol-parvalbumin pathway alter learning and memory, and whether BDNF may mediate these events. Wild-type (WT) and BDNF heterozygous (+/-) mice were ovariectomized (OVX) at 5 weeks of age and simultaneously received empty, estradiol- or progesterone-filled implants for 7 weeks. At young adulthood, mice were tested for spatial and recognition memory in the Y-maze and novel-object recognition test, respectively. Hippocampal protein expression of BDNF and GABAergic interneuron markers, including parvalbumin, were assessed. WT OVX mice show impaired performance on Y-maze and novel-object recognition test. Estradiol replacement in OVX mice prevented the Y-maze impairment, a Behavioral abnormality of dorsal hippocampal origin. BDNF and parvalbumin protein expression in the dorsal hippocampus and parvalbumin-positive cell number in the dorsal CA1 were significantly reduced by OVX in WT mice, while E2 replacement prevented these deficits. In contrast, BDNF(+/-) mice showed either no response or an opposite response to hormone manipulation in both behavioral and molecular indices. Our data suggest that BDNF status is an important biomarker for predicting responsiveness to estrogenic compounds which have emerged as promising adjunctive therapeutics for schizophrenia patients.

Indexed as

AnimalsBehavior, AnimalBrain-Derived Neurotrophic FactorCA1 Region, HippocampalEstradiolEstrogensFemaleGene-Environment InteractionHeterozygoteHippocampusMaze LearningMiceMice, Inbred C57BLOvariectomyParvalbuminsSpatial MemoryBrain-Derived Neurotrophic FactorEstradiolEstrogensParvalbumins

Identifiers

PMID25603414
PMCPMC4312832
OpenAlexW2017391227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.