ArticleMarine drugs2015
Biosynthesis of akaeolide and lorneic acids and annotation of type I polyketide synthase gene clusters in the genome of Streptomyces sp. NPS554.
Article in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Plug-and-play engineering of modular polyketide synthases.Nature chemical biology · 2025Article
- Cryptoic acids A and B, benzene-containing polyketides, and cyclocryptamide, a modified diketopiperazine, from an actinomycete of the genus Cryptosporangium.The Journal of antibiotics · 2025Article
- Biosynthesis of trialkyl-substituted aromatic polyketide NFAT-133 involves unusual P450 monooxygenase-mediating aromatization and a putative metallo-beta-lactamase fold hydrolase.Synthetic and systems biotechnology · 2023Article
- Unusual Secondary Metabolites from the Mangrove Ecosystems: Structures, Bioactivities, Chemical, and Bio-Syntheses.Marine drugs · 2022Review
- The Tetrahydrofuran Motif in Polyketide Marine Drugs.Marine drugs · 2022Review
- Complete Genome Sequence of Two Deep-SeaMarine drugs · 2021Article
- Biosynthesis of the Nuclear Factor of Activated T Cells Inhibitor NFAT-133 inACS chemical biology · 2020Article
- Metagenomics Approaches in Discovery and Development of New Bioactive Compounds from Marine Actinomycetes.Current microbiology · 2020Review
- Cytochrome P450 Monooxygenase CYP139 Family Involved in the Synthesis of Secondary Metabolites in 824 Mycobacterial Species.International journal of molecular sciences · 2019Article
- The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines.Chemical reviews · 2017Review
- Polyketide stereocontrol: a study in chemical biology.Beilstein journal of organic chemistry · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incorporation pattern of biosynthetic precursors into two structurally unique polyketides, akaeolide and lorneic acid A, was elucidated by feeding experiments with 13C-labeled precursors. In addition, the draft genome sequence of the producer, Streptomyces sp. NPS554, was performed and the biosynthetic gene clusters for these polyketides were identified. The putative gene clusters contain all the polyketide synthase (PKS) domains necessary for assembly of the carbon skeletons. Combined with the 13C-labeling results, gene function prediction enabled us to propose biosynthetic pathways involving unusual carbon-carbon bond formation reactions. Genome analysis also indicated the presence of at least ten orphan type I PKS gene clusters that might be responsible for the production of new polyketides.
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