ArticleMarine drugs2015
Isolation and assessment of the in vitro anti-tumor activity of smenothiazole A and B, chlorinated thiazole-containing peptide/polyketides from the Caribbean sponge, Smenospongia aurea.
Article in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Natural Products Derived from Marine Sponges with Antitumor Potential against Lung Cancer: A Systematic Review.Marine drugs · 2024Pooled it
- Spatial and Temporal Resolution of Cyanobacterial Bloom Chemistry Reveals an Open-OceanEnvironmental science & technology · 2024Article
- Novel Insights in the Potential of Halogenated Polyketide-Peptide Molecules as Lead Compounds in Cancer Drug Discovery.International journal of molecular sciences · 2023Article
- Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023Review
- GenusMolecules (Basel, Switzerland) · 2022Review
- Isolation of Isotrichophycin C and Trichophycins G-I from a Collection ofJournal of natural products · 2020Article
- Marine natural products from sponges (Porifera) of the order Dictyoceratida (2013 to 2019); a promising source for drug discovery.RSC advances · 2020Review
- Fast Detection of Two Smenamide Family Members Using Molecular Networking.Marine drugs · 2019Article
- Mass Spectrometry-Based Integration and Expansion of the Chemical Diversity Harbored Within a Marine Sponge.Journal of the American Society for Mass Spectrometry · 2019Article
- A joint molecular networking study of aOrganic chemistry frontiers : an international journal of organic chemistry · 2019Article
- Isolation of Smenopyrone, a Bis-γ-Pyrone Polypropionate from the Caribbean SpongeMarine drugs · 2018Article
- Smenamide A Analogues. Synthesis and Biological Activity on Multiple Myeloma Cells.Marine drugs · 2018Article
- The Metabolome of a Cyanobacterial Bloom Visualized by MS/MS-Based Molecular Networking Reveals New Neurotoxic Smenamide Analogs (C, D, and E).Frontiers in chemistry · 2018Article
- Evaluating the Effects of an Organic Extract from the Mediterranean Sponge Geodia cydonium on Human Breast Cancer Cell Lines.International journal of molecular sciences · 2017Article
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- Plakofuranolactone as a Quorum Quenching Agent from the Indonesian Sponge Plakortis cf. lita.Marine drugs · 2017Article
- Quorum Sensing Inhibitors from the Sea Discovered Using Bacterial N-acyl-homoserine Lactone-Based Biosensors.Marine drugs · 2017Review
- Marine Organisms with Anti-Diabetes Properties.Marine drugs · 2016Review
- A New N-Acyl Homoserine Lactone Synthase in an Uncultured Symbiont of the Red Sea Sponge Theonella swinhoei.Applied and environmental microbiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.