ArticleBiological psychology2015
Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients.
Article in Biological psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02069925 (STEP-ED), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
STEP-ED: Reducing Duration of Untreated Psychosis and Its Impact in the U.S.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Investigating event-related potential (ERP) deviations in clinical high-risk populations for psychosis: a systematic review and meta-analysis.BMC psychiatry · 2026Pooled it
- Meta-analysis of mismatch negativity to simple versus complex deviants in schizophrenia.Schizophrenia research · 2018Pooled it
- Reliability of mismatch negativity event-related potentials in a multisite, traveling subjects study.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Trial
- Interactive effects of an N-methyl-d-aspartate receptor antagonist and a nicotinic acetylcholine receptor agonist on mismatch negativity: Implications for schizophrenia.Schizophrenia research · 2018Trial
- Theta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity.Biological psychiatry global open science · 2026Article
- The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures.Schizophrenia (Heidelberg, Germany) · 2025Article
- Development of Biomarkers Potentially Sensitive to Early Psychosis Using Mismatch Negativity (MMN) to Complex Pattern Deviations.Clinical EEG and neuroscience · 2025Article
- Neurophysiological Models in Individuals at Clinical High Risk for Psychosis: Using Translational EEG Paradigms to Forecast Psychosis Risk and Resilience.Advances in neurobiology · 2024Review
- Biomarkers for Psychosis: Are We There Yet? Umbrella Review of 1478 Biomarkers.Schizophrenia bulletin open · 2024Article
- Musicians show more integrated neural processing of contextually relevant acoustic features.Frontiers in neuroscience · 2022Article
- Electroencephalography and Event-Related Potential Biomarkers in Individuals at Clinical High Risk for Psychosis.Biological psychiatry · 2020Review
- Reward processing electrophysiology in schizophrenia: Effects of age and illness phase.NeuroImage. Clinical · 2020Article
- Parsing components of auditory predictive coding in schizophrenia using a roving standard mismatch negativity paradigm.Psychological medicine · 2019Article
- Differential of Frequency and Duration Mismatch Negativity and Theta Power Deficits in First-Episode and Chronic Schizophrenia.Frontiers in behavioral neuroscience · 2019Article
- Mismatch Negativity But Not P300 Is Associated With Functional Disability in Schizophrenia.Schizophrenia bulletin · 2018Article
- Neurobiological Determinants of Tobacco Smoking in Schizophrenia.Frontiers in psychiatry · 2018Review
- Neural mechanisms of mismatch negativity dysfunction in schizophrenia.Molecular psychiatry · 2017Article
- Brief Report: Biological Sound Processing in Children with Autistic Spectrum Disorder.Journal of autism and developmental disorders · 2017Article
- Reduced Mismatch Negativity is Associated with Increased Plasma Level of Glutamate in First-episode Psychosis.Scientific reports · 2017Article
- Trait aspects of auditory mismatch negativity predict response to auditory training in individuals with early illness schizophrenia.Neuropsychiatric electrophysiology · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Neurophysiological abnormalities in auditory deviance processing, as reflected by the mismatch negativity (MMN), have been observed across the course of schizophrenia. Studies in early schizophrenia patients have typically shown varying degrees of MMN amplitude reduction for different deviant types, suggesting that different auditory deviants are uniquely processed and may be differentially affected by duration of illness. To explore this further, we examined the MMN response to 4 auditory deviants (duration, frequency, duration+frequency "double deviant", and intensity) in 24 schizophrenia-spectrum patients early in the illness (ESZ) and 21 healthy controls. ESZ showed significantly reduced MMN relative to healthy controls for all deviant types (p<0.05), with no significant interaction with deviant type. No correlations with clinical symptoms were present (all ps>0.05). These findings support the conclusion that neurophysiological mechanisms underlying processing of auditory deviants are compromised early in illness, and these deficiencies are not specific to the type of deviant presented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.