Evidence map›Paper›PMID 25603281›Full record

ArticleTranscription2015

Recent insights into Groucho co-repressor recruitment and function.

Aamna K Kaul, Eugene F Schuster, Barbara H Jennings

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transcription, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Integration of Wnt and FGF signaling in theDevelopment (Cambridge, England) · 2019
    Article
  3. Article
  4. Voluntary exposure to a toxin: the genetic influence on ethanol consumption.Mammalian genome : official journal of the International Mammalian Genome Society · 2018
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aamna K Kaula Department of Genetics, Evolution and Environment ; University College London ; London , United Kingdom.
Eugene F Schuster
Barbara H Jennings

Funding

Medical Research Council G0800310Wellcome Trust
6 · The paper itself

Abstract

Gene expression is often controlled by transcriptional repressors during development. Many transcription factors lack intrinsic repressive activity but recruit co-factors that inhibit productive transcription. Here we discuss new insights and models for repression mediated by the Groucho/Transducin-Like Enhancer of split (Gro/TLE) family of co-repressor proteins.

Indexed as

Transcription, GeneticAnimalsCo-Repressor ProteinsHumansRepressor ProteinsCo-Repressor ProteinsRepressor ProteinsTLE5 protein, humanbHLH, basic helix-loop-helixChIP-seq, chromatin immunoprecipitation followed by high throughput sequencing, qPCR, quantitative PCRCRISPR, Clustered Regularly Interspaced Short Palindromic RepeatDrosophilaDrosophila, Drosophila melanogaster, Gro, GrouchoE(spl), enhancer of splitGAF, GAGA Factor; NELF, Negative Elongation FactorGro/TLE, Groucho/Transducin-like enhancer of splitGroucho/TLEkb, kilobaseP-TEFb, Positive Elongation Factor brepressorRNAP II, RNA polymerase IIRNA polymerase pausingTALENs, Transcription Activator-Like Effector Nucleasestranscriptional repressiontranscription factorTSS, transcription start site

Identifiers

PMID25603281
PMCPMC4422819

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.