ArticleBiomedical engineering online2015
Experimental study of hemodynamics in the Circle of Willis.
Article in Biomedical engineering online, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- A Subject-Specific Cerebrovascular CFD Modeling Approach Based on a Multimodal Data-Driven Boundary Calibration Framework: A Proof-of-Concept Study.Bioengineering (Basel, Switzerland) · 2026Article
- Lack of Anterior Communicating Artery Is Associated with Symptomatic Middle Cerebral Artery Atherosclerosis.Biomedicines · 2026Article
- Multiscale modeling of blood circulation with cerebral autoregulation and network pathway analysis for hemodynamic redistribution in the vascular network with anatomical variations and stenosis conditions.PLoS computational biology · 2026Article
- Strategies for Navigating Magnetic Microrobots in Neurovascular Networks: A Numerical Analysis.Small science · 2025Article
- Accurate full-scale patient-specific Circle of Willis models including aneurysms: A novel manufacturing approach.PloS one · 2025Article
- Numerical study on the cerebral blood flow regulation in the circle of Willis with the vascular absence and internal carotid artery stenosis.Frontiers in bioengineering and biotechnology · 2024Article
- An analytical method informed by clinical imaging data for estimating outlet boundary conditions in computational fluid dynamics analysis of carotid artery blood flow.Scientific reports · 2023Article
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- Contrast thresholds for detection of various iodine concentrations in subtraction CT and dual-energy CT systems.Journal of applied clinical medical physics · 2023Article
- On non-Kolmogorov turbulence in blood flow and its possible role in mechanobiological stimulation.Scientific reports · 2022Article
- Investigation of Flow Changes in Intracranial Vascular Disease Models Constructed with MRA Images.Sensors (Basel, Switzerland) · 2022Article
- Computer Modeling of Clot Retrieval-Circle of Willis.Frontiers in neurology · 2020Article
- PIV investigation of the flow fields in subject-specific vertebro-basilar (VA-BA) junction.Biomedical engineering online · 2019Article
- Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms.Medicina (Kaunas, Lithuania) · 2019Article
- Cerebral Artery Hypoplasia among Black Kenyans.Journal of neurosciences in rural practice · 2019Article
- Genetic and Environmental Contributions to Variation in the Posterior Communicating Collaterals of the Circle of Willis.Translational stroke research · 2019Article
- Cardiovagal and adrenergic function tests in unilateral carotid artery stenosis patients-a Valsalva manoeuvre tool to show an autonomic dysfunction?Wiener klinische Wochenschrift · 2016Article
- The role of the circle of Willis in internal carotid artery stenosis and anatomical variations: a computational study based on a patient-specific three-dimensional model.Biomedical engineering online · 2015Article
- Cardiovascular diseases and vulnerable plaques: data, modeling, predictions and clinical applications.Biomedical engineering online · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Circle of Willis (CoW) is an important collateral pathway of the cerebral blood flow. An experimental study of the cerebral blood flow (CBF) distribution in different anatomical variations may help to a better understanding of the collateral mechanism of the CoW.
methodsAn in-vitro test rig was developed to simulate the physiological cerebral blood flow in the CoW. Ten anatomical variations were considered in this study, include a set of different degrees of stenosis in L-ICA and L-ICA occlusion coexist with common anatomical variations. Volume flow rates of efferent arteries and pressure signals at the end of communicating arteries of each case were recorded. Physiological pressure waveforms were applied as inlet boundary condition.
resultsIn the development of L-ICA stenosis, the total CBF decreases with the increase of stenosis degree. The blood supply of ipsilateral middle cerebral artery (MCA) was affected most by the stenosis of L-ICA. Anterior communicating artery (ACoA) and ipsilateral posterior communicating artery (PCoA) function as important collateral pathways of cerebral collateral circulation when unilateral stenosis occurred. The blood supply of anterior cerebral circulation was compensated by the posterior cerebral circulation through ipsilateral PCoA when L-ICA stenosis degree is greater than 40% and the affected side was compensated immediately by the unaffected side through ACoA. Blood flow of the anterior circulation and the total CBF reached the minimum among all cases studied when L-ICA occlusion coexist with the absence of PCoA.
conclusionThe results demonstrated the flow distribution patterns of the CoW under anatomical variations and clarified the collateral mechanism of the CoW. The flow ACoA is the most sensitive indexes to the morphology change of ipsilateral ICA. The relative independence of the circulation in anterior and posterior sections of the CoW is not broken and the function of ipsilateral PCoA is not activated until a severe stenosis of unilateral ICA occurs. PCoA is the most important collateral pathway of the collateral circulation and the missing of PCoA has the highest risk of stroke when the ipsilateral ICA has severe stenosis. These findings may provide the basis for future therapeutic and diagnosis applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.