ArticlePloS one2015
Persistent high IgG phase I antibody levels against Coxiella burnetii among veterinarians compared to patients previously diagnosed with acute Q fever after three years of follow-up.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Exposure of South African Abattoir Workers toTropical medicine and infectious disease · 2022Article
- High prevalence ofVeterinary world · 2020Article
- Article
- Article
- Coxiella burnetii Epitope-Specific T-Cell Responses in Patients with Chronic Q Fever.Infection and immunity · 2019Article
- Serological evidence ofInfection and drug resistance · 2019Article
- Acute Q fever in febrile patients in northwestern of Iran.PLoS neglected tropical diseases · 2017Article
- Improved correlation of human Q fever incidence to modelled C. burnetii concentrations by means of an atmospheric dispersion model.International journal of health geographics · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the development of chronic Q fever in occupational risk groups. The aim of this study was to perform long-term follow-up of Coxiella burnetii seropositive veterinarians and investigate the course of IgG phase I and phase II antibodies against C. burnetii antigens and to compare this course with that in patients previously diagnosed with acute Q fever.
methodsVeterinarians with IgG phase I ≥ 1:256 (immunofluorescence assay) that participated in a previous seroprevalence study were asked to provide a second blood sample three years later. IgG antibody profiles were compared to a group of acute Q fever patients who had IgG phase I ≥ 1:256 twelve months after diagnosis.
resultsIgG phase I was detected in all veterinarians (n = 76) and in 85% of Q fever patients (n = 98) after three years (p<0.001). IgG phase I ≥ 1:1,024, indicating possible chronic Q fever, was found in 36% of veterinarians and 12% of patients (OR 3.95, 95% CI: 1.84-8.49).
conclusionsIgG phase I persists among veterinarians presumably because of continuous exposure to C. burnetii during their work. Serological and clinical follow-up of occupationally exposed risk groups should be considered.
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