ArticleConnective tissue research2015
Observation of sGAG content of human hip joint cartilage in different old age groups based on EPIC micro-CT.
Article in Connective tissue research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Modern experimental methods for assessing the effectiveness of tissue-engineered products for hyaline cartilage regeneration.Frontiers in bioengineering and biotechnology · 2025Review
- In vivo biochemical assessment of cartilage with gagCEST MRI: Correlation with cartilage properties.NMR in biomedicine · 2021Article
- An impaired healing model of osteochondral defect in papain-induced arthritis.Journal of orthopaedic translation · 2021Article
- Mitigation of Articular Cartilage Degeneration and Subchondral Bone Sclerosis in Osteoarthritis Progression Using Low-Intensity Ultrasound Stimulation.Ultrasound in medicine & biology · 2019Article
- Morphological, biochemical and mechanical properties of articular cartilage and subchondral bone in rat tibial plateau are age related.Journal of anatomy · 2018Article
- Murine articular cartilage morphology and compositional quantification with high resolution cationic contrast-enhanced μCT.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesTo observe the age-related changes of sulfated glycosaminoglycan (sGAG) content of hip joint cartilage of elderly people based on Equilibrium Partitioning of an Ionic Contrast Agent (EPIC) micro-CT.
methodsSeventy human hip cartilage-bone samples were collected from hip-fracture patients (ages 51-96) and divided into five groups (10 years in an age group). They were first immersed in 20% concentration of the contrast agent Meglumine Diatrizoate (MD) for 6 h at 37 °C, and then scanned by micro-CT. Following scanning, samples were stained for sGAG with toluidine blue. The X-ray attenuation and sGAG optical density were calculated by image processing. The correlation between X-ray attenuation and sGAG optical density was then analyzed.
resultsThe X-ray mean attenuation of the cartilage increased by 18.81% from the 50-80 age groups (p < 0.01), but decreased by 7.15% in the 90 age group compared to the 80 age group. The X-ray mean attenuation of the superficial layer and middle layer increased by 31.60 % and 44.68% from the 50-80 age groups, respectively (p < 0.01), but reduced by 4.67% and 6.05% separately in the 90 age group. However, the deep layer showed no significant change with aging. The sGAG optical density showed a linear correlation (r = -0.91, p < 0.01) with the X-ray attenuation.
conclusionThe sGAG content of hip joint cartilage varied with aging in elderly people. The changes in superficial layer and middle layer were more evident than deep layer.
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