ArticleBiomedical engineering online2015
Influence of model boundary conditions on blood flow patterns in a patient specific stenotic right coronary artery.
Article in Biomedical engineering online, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Sensitivity of coronary hemodynamics to vascular structure variations in health and disease.Scientific reports · 2025Article
- The Influence of Aortic Valve Disease on Coronary Hemodynamics: A Computational Model-Based Study.Bioengineering (Basel, Switzerland) · 2023Article
- Asymmetric distribution of pathogenic low wall shear stress of the bilateral subclavian arteries: two case reports.The Journal of international medical research · 2021Article
- Towards a better understanding of the posttreatment hemodynamic behaviors in femoropopliteal arteries through personalized computational models based on OCT images.Scientific reports · 2021Article
- Boundary conditions investigation to improve computer simulation of cerebrospinal fluid dynamics in hydrocephalus patients.Communications biology · 2021Article
- Computational Analysis of the Pulmonary Arteries in Congenital Heart Disease: A Review of the Methods and Results.Computational and mathematical methods in medicine · 2021Review
- An Introduction to Biomedical Computational Fluid Dynamics.Advances in experimental medicine and biology · 2021Article
- Virtual FFR Quantified with a Generalized Flow Model Using Windkessel Boundary Conditions.Computational and mathematical methods in medicine · 2020Article
- Prediction of restenosis based on hemodynamical markers in revascularized femoro-popliteal arteries during leg flexion.Biomechanics and modeling in mechanobiology · 2019Article
- Hemodynamic numerical simulations of the disturbance due to intracoronary flow measurements by a Doppler guide wire.Biomedical engineering online · 2016Article
- Cardiovascular diseases and vulnerable plaques: data, modeling, predictions and clinical applications.Biomedical engineering online · 2015Article
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Abstract
backgroundIn literature, the effect of the inflow boundary condition was investigated by examining the impact of the waveform and the shape of the spatial profile of the inlet velocity on the cardiac hemodynamics. However, not much work has been reported on comparing the effect of the different combinations of the inlet/outlet boundary conditions on the quantification of the pressure field and flow distribution patterns in stenotic right coronary arteries.
methodNon-Newtonian models were used to simulate blood flow in a patient-specific stenotic right coronary artery and investigate the influence of different boundary conditions on the phasic variation and the spatial distribution patterns of blood flow. The 3D geometry of a diseased artery segment was reconstructed from a series of IVUS slices. Five different combinations of the inlet and the outlet boundary conditions were tested and compared.
resultsThe temporal distribution patterns and the magnitudes of the velocity, the wall shear stress (WSS), the pressure, the pressure drop (PD), and the spatial gradient of wall pressure (WPG) were different when boundary conditions were imposed using different pressure/velocity combinations at inlet/outlet. The maximum velocity magnitude in a cardiac cycle at the center of the inlet from models with imposed inlet pressure conditions was about 29% lower than that from models using fully developed inlet velocity data. Due to the fact that models with imposed pressure conditions led to blunt velocity profile, the maximum wall shear stress at inlet in a cardiac cycle from models with imposed inlet pressure conditions was about 29% higher than that from models with imposed inlet velocity boundary conditions. When the inlet boundary was imposed by a velocity waveform, the models with different outlet boundary conditions resulted in different temporal distribution patterns and magnitudes of the phasic variation of pressure. On the other hand, the type of different boundary conditions imposed at the inlet and the outlet did not have significant effect on the spatial distribution patterns of the PD, the WPG and the WSS on the lumen surface, regarding the locations of the maximum and the minimum of each quantity.
conclusionsThe observations from this study indicated that the ways how pressure and velocity boundary conditions are imposed in computational models have considerable impact on flow velocity and shear stress predictions. Accuracy of in vivo measurements of blood pressure and velocity is of great importance for reliable model predictions.
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