Evidence map›Paper›PMID 25602366›Full record

ArticleCell cycle (Georgetown, Tex.)2015

MiR-194, commonly repressed in colorectal cancer, suppresses tumor growth by regulating the MAP4K4/c-Jun/MDM2 signaling pathway.

Bo Wang, Zhan-long Shen, Zhi-dong Gao, Gang Zhao, Chun-you Wang, Yang Yang, Ji-zhun Zhang, Yi-chao Yan, Chao Shen, Ke-wei Jiang and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.

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  19. MicroRNA Assisted Gene Regulation in Colorectal Cancer.International journal of molecular sciences · 2019
    Article
  20. microRNA-520c-3p suppresses NLRP3 inflammasome activation and inflammatory cascade in preeclampsia by downregulating NLRP3.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Bo Wanga Department of Gastroenterological Surgery ; Peking University People's Hospital ; Beijing , PR China.
Zhan-long Shen
Zhi-dong Gao
Gang Zhao
Chun-you Wang
Yang Yang
Ji-zhun Zhang
Yi-chao Yan
Chao Shen
Ke-wei Jiang
Ying-jiang Ye
Shan Wang
Peking University · CNBeijing Administration Institute · CNPeking University People's Hospital · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor growth cascade is a complicated and multistep process with numerous obstacles. Until recently, evidences have shown the involvement of microRNAs (miRNAs) in tumorigenesis and tumor progression of various cancers, including colorectal cancer (CRC). In this study, we explored the role of miR-194 and its downstream pathway in CRC. We acquired data through miRNA microarray profiles, showing that the expression of miR-194 was significantly suppressed in CRC tissues compared with corresponding noncancerous tissues. Decreased miR-194 expression was obviously associated with tumor size and tumor differentiation, as well as TNM stage. Both Kaplan-Meier and multivariate survival analysis showed that downregulated miR-194 was associated with overall survival. Moreover, functional assays indicated that overexpression of miR-194 in CRC cell lines inhibited cell proliferation both in vitro and in vivo. In addition, using dual-luciferase reporter gene assay, we found MAP4K4 was the direct target of miR-194. Silencing of MAP4K4 resulted in similar biological behavior changes to that of overexpression of miR-194. We also observed through Human Gene Expression Array that MDM2 was one of the downstream targets of MAP4K4. Knockdown of MAP4K4 downregulated MDM2 expression through transcription factor c-Jun binding to the -1063 to -1057 bp of the promoter. These results suggest that miR-194, regulating the MAP4K4/c-Jun/MDM2 signaling pathway, might act as a tumor suppressor and serve as a novel target for CRC prevention and therapy.

Indexed as

3' Untranslated RegionsAnimalsApoptosisBase SequenceBinding SitesCell Line, TumorCell ProliferationColorectal NeoplasmsDown-RegulationFemaleG1 Phase Cell Cycle CheckpointsGene ExpressionGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsKaplan-Meier Estimate3' Untranslated RegionsIntracellular Signaling Peptides and ProteinsMAP4K4 protein, humanMDM2 protein, humanMicroRNAsMIRN194 microRNA, humanProtein Serine-Threonine KinasesProto-Oncogene Proteins c-junProto-Oncogene Proteins c-mdm2apoptosisc-Juncolorectal cancerMAP4K4MDM2miR-194proliferation

Identifiers

PMID25602366
PMCPMC4615039
OpenAlexW1623600373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.