ArticleRehabilitation psychology2015
Pain affects depression through anxiety, fatigue, and sleep in multiple sclerosis.
Article in Rehabilitation psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07741864 (Effectiveness of a Mindfulness-Based Intervention for Pain Management in Patients With Multiple Sclerosis), which is not on this map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of a Mindfulness-Based Intervention for Pain Management in Patients With Multiple Sclerosis
Who cites it
60 citing papers in PubMed, 122 citations in OpenAlex.
- Objective Ischemia, Subjective Angina, and Psychological Distress in Angina With No Obstructive Coronary Disease.Journal of the American Heart Association · 2024Trial
- Smartphone based behavioral therapy for pain in multiple sclerosis (MS) patients: A feasibility acceptability randomized controlled study for the treatment of comorbid migraine and ms pain.Multiple sclerosis and related disorders · 2020Trial
- Combined upper limb and breathing exercise programme for pain management in ambulatory and non-ambulatory multiple sclerosis individuals: part II analyses from feasibility study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Trial
- Association of neuropathic pain with bladder and bowel dysfunction, functional disability, and quality of life of patients with multiple sclerosis.Turkish journal of physical medicine and rehabilitation · 2026Article
- Long-Lasting Changes of Repeated Anodal Transcranial Direct Current Stimulation in Decreasing Chronic Pain in Patients with Multiple Sclerosis: A Case Series.Brain sciences · 2026Article
- Bidirectional association between immune-mediated diseases and major depressive disorder: evidence from cohort, genome-wide pleiotropic, and experimental studies.Molecular psychiatry · 2026Article
- Understanding Sleep Challenges in Pediatric Palliative Care: A Patient-Focused Scoping Review and Implications for Practice.Journal of clinical medicine · 2026Review
- Article
- Impaired Molecular Mechanisms Contributing to Chronic Pain in Patients with Hidradenitis Suppurativa: Exploring Potential Biomarkers and Therapeutic Targets.International journal of molecular sciences · 2025Article
- Psychological states mediate the relationship between sleep quality and frailty among older adults.Frontiers in psychology · 2025Article
- Factors affecting fatigue progression in multiple sclerosis patients.Scientific reports · 2024Article
- Findings Consistent with a Breast Implant-associated Somatic System Disorder (BIA-SSD) Among Patients Self-reporting Breast Implant Illness.Plastic and reconstructive surgery. Global open · 2024Article
- Psychosocial Outcomes of Pain and Pain Management in Adults with Osteogenesis Imperfecta: A Qualitative Study.Journal of clinical psychology in medical settings · 2024Article
- The role of fatigue in patients with complex regional pain syndrome.Journal of neurology · 2024Article
- Pain-Insomnia-Depression Syndrome: Triangular Relationships, Pathobiological Correlations, Current Treatment Modalities, and Future Direction.Pain and therapy · 2024Review
- Mendelian randomization highlights sleep disturbances mediated the effect of depression on chronic pain.Brain and behavior · 2024Article
- Sleep Disorders and Fatigue among Patients with MS: The Role of Depression, Stress, and Anxiety.Neurology research international · 2024Article
- MS care: integrating advanced therapies and holistic management.Frontiers in neurology · 2023Review
- Relationship between Physical Activity and Emotional Regulation Strategies in Early Adulthood: Mediating Effects of Cortical Thickness.Brain sciences · 2022Article
- Barriers to quality of life in patients with multiple sclerosis: a qualitative study.BMC neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveOver a quarter million individuals in the United States have multiple sclerosis (MS). Chronic pain and depression are disproportionately high in this population. The purpose of this study was to examine the relationship between chronic pain and depression in MS and to examine potentially meditational effects of anxiety, fatigue, and sleep.
methodWe used cross-sectional data from self-reported instruments measuring multiple symptoms and quality of life indicators in this study. We used structural equation modeling to model direct and indirect effects of pain on depression in a sample of 1,245 community-dwelling individuals with MS. Pain interference, depression, fatigue, and sleep disturbance were modeled as latent variables with 2 to 3 indicators each. The model controlled for age, sex, disability status (Expanded Disability Status Scale), and social support.
resultsA model with indirect effects of pain on depression had adequate fit and accounted for nearly 80% of the variance in depression. The effects of chronic pain on depression were almost completely mediated by fatigue, anxiety, and sleep disturbance. Higher pain was associated with greater fatigue, anxiety, and sleep disturbance, which in turn were associated with higher levels of depression. The largest mediating effect was through fatigue. Additional analyses excluded items with common content and suggested that the meditational effects observed were not attributable to content overlap across scales.
conclusionIndividuals living with MS who report high levels of chronic pain and depressive symptoms may benefit from treatment approaches that can address sleep, fatigue, and anxiety.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.