Evidence map›Paper›PMID 25602243›Full record

ReviewCurrent opinion in psychiatry2015

Brain imaging research in autism spectrum disorders: in search of neuropathology and health across the lifespan.

Janet E Lainhart

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Trajectory research in children with an autism diagnosis: A scoping review.Autism : the international journal of research and practice · 2024
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. [Abnormal brain structure in preschool and school-aged children with autism spectrum disorder].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019
    Article
  15. Article
  16. Review
  17. Article
  18. Modeling autism in non-human primates: Opportunities and challenges.Autism research : official journal of the International Society for Autism Research · 2018
    Review
  19. Loss of skills and onset patterns in neurodevelopmental disorders: Understanding the neurobiological mechanisms.Autism research : official journal of the International Society for Autism Research · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Janet E LainhartWaisman Laboratory for Brain Imaging and Behavior, and Autism & Developmental Disorders Clinic, Waisman Center, and Department of Psychiatry, University of Wisconsin-Madison, Wisconsin, USA.
University of Wisconsin–Madison · US

Funding

WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SVAREN, JOHN P · 1985 to 2015
$25.2M
Atypical Late Neurodevelopment in Autism: A Longitudinal MRI and DTI StudyR01MH080826 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI LAINHART, JANET ELIZABETH · 2007 to 2020
$6.5M
Biological Determinants of Brain Variation in AutismR01MH097464 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI LAINHART, JANET ELIZABETH, LANGE, NICHOLAS T · 2013 to 2017
$2.9M
The Microstructural Basis of Abnormal Connectivity in AutismR01MH084795 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI LAINHART, JANET ELIZABETH · 2009 to 2013
$1.9M
NICHD NIH HHS P30 HD003352NIMH NIH HHS R01 MH080826NIMH NIH HHS R01 MH084795NIMH NIH HHS R01 MH097464PHS HHS P30 IHD003352
6 · The paper itself

Abstract

purpose of reviewAdvances in brain imaging research in autism spectrum disorders (ASD) are rapidly occurring, and the amount of neuroimaging research has dramatically increased over the past 5 years. In this review, advances during the past 12 months and longitudinal studies are highlighted. RECENT

findingsCross-sectional neuroimaging research provides evidence that the neural underpinnings of the behavioral signs of ASD involve not only dysfunctional integration of information across distributed brain networks but also basic dysfunction in primary cortices.Longitudinal studies of ASD show abnormally enlarged brain volumes and increased rates of brain growth during early childhood in only a small minority of ASD children. There is evidence of disordered development of white matter microstructure and amygdala growth, and at 2 years of age, network inefficiencies in posterior cerebral regions.From older childhood into adulthood, atypical age-variant and age-invariant changes in the trajectories of total and regional brain volumes and cortical thickness are apparent at the group level. SUMMARY: There is evidence of abnormalities in posterior lobes and posterior brain networks during the first 2 years of life in ASD and, even in older children and adults, dysfunction in primary cortical areas.

Indexed as

BrainChild Development Disorders, PervasiveHumansNeuroimaging

Identifiers

PMID25602243
PMCPMC4465432
OpenAlexW2040436032

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.