ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
A review of inter- and intraspecific variation in the eutherian placenta.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024Guideline
- Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.Nature communications · 2019Pooled it
- Gestational Changes in Placental Iron Homeostasis are Associated With Ferroptosis-Associated Redox Signaling and Trophoblast Behavior.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Inhibition of p65 nuclear translocation in decidual stromal cells underlies COS-induced supraphysiologic estrogen impairment of uNK cell function which drives placental abnormalities.Journal of translational medicine · 2026Article
- Cross-species insights into placental evolution and diseases at the single-cell resolution.Nature communications · 2026Article
- Endogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk.Genome biology · 2026Article
- Maternal-fetal conflict and the timing of birth.Evolution, medicine, and public health · 2025Review
- Primate amnion development.Development (Cambridge, England) · 2024Review
- Deciphering the Epigenetic Landscape: Placental Development and Its Role in Pregnancy Outcomes.Stem cell reviews and reports · 2024Review
- Animal Models ofPathogens (Basel, Switzerland) · 2022Review
- Animal Models of Cardiovascular Complications of Pregnancy.Circulation research · 2022Review
- Tracing the cis-regulatory changes underlying the endometrial control of placental invasion.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- On Placental Toxicology Studies and Cerium Dioxide Nanoparticles.International journal of molecular sciences · 2021Review
- Leftovers of viruses in human physiology.Brain structure & function · 2021Review
- AT-rich interactive domain 1A protein expression in normal and pathological pregnancies complicated by preeclampsia.Histochemistry and cell biology · 2020Article
- Advancing human health in the decade ahead: pregnancy as a key window for discovery: A Burroughs Wellcome Fund Pregnancy Think Tank.American journal of obstetrics and gynecology · 2020Article
- The role of extracellular matrix in normal and pathological pregnancy: Future applications of microphysiological systems in reproductive medicine.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Lifetime cancer prevalence and life history traits in mammals.Evolution, medicine, and public health · 2020Article
- The placenta goes viral: Retroviruses control gene expression in pregnancy.PLoS biology · 2018Article
- Hemochorial placentation: development, function, and adaptations.Biology of reproduction · 2018Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The placenta is one of the most morphologically variable mammalian organs. Four major characteristics are typically discussed when comparing the placentas of different eutherian species: placental shape, maternal-fetal interdigitation, intimacy of the maternal-fetal interface and the pattern of maternal-fetal blood flow. Here, we describe the evolution of three of these features as well as other key aspects of eutherian placentation. In addition to interspecific anatomical variation, there is also variation in placental anatomy and function within a single species. Much of this intraspecific variation occurs in response to different environmental conditions such as altitude and poor maternal nutrition. Examinations of variation in the placenta from both intra- and interspecies perspectives elucidate different aspects of placental function and dysfunction at the maternal-fetal interface. Comparisons within species identify candidate mechanisms that are activated in response to environmental stressors ultimately contributing to the aetiology of obstetric syndromes such as pre-eclampsia. Comparisons above the species level identify the evolutionary lineages on which the potential for the development of obstetric syndromes emerged.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.